Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice

ABSTRACT In rodents, many exogenous and endogenous cannabinoids, such as anandamide (AEA) and 2‐arachidonyl glycerol (2‐AG), have been shown to play an important role in certain hippocampal memory processes. However, the mechanisms by which endogenous AEA regulate this processes are not well underst...

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Bibliographic Details
Published in:	Hippocampus Vol. 24; no. 7; pp. 808 - 818
Main Authors:	Basavarajappa, Balapal S., Nagre, Nagaraja N., Xie, Shan, Subbanna, Shivakumar
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-07-2014 Wiley Subscription Services, Inc
Subjects:	Amidohydrolases - antagonists & inhibitors anandamide Animals Arachidonic Acids - physiology Benzamides - pharmacology Calcium-Calmodulin-Dependent Protein Kinase Type 4 - physiology CaMKIV phosphorylation Carbamates - pharmacology CB1 null mice CREB Cyclic AMP Response Element-Binding Protein - physiology Endocannabinoids - physiology fatty acid amide hydrolase Glycerides - physiology Learning - physiology long-term potentiation Long-Term Potentiation - physiology Male MAP Kinase Signaling System - physiology Maze Learning - physiology Memory - physiology Mice Mice, Inbred C57BL Mice, Knockout mitogen-activated protein kinase Phosphorylation Polyunsaturated Alkamides Protein Processing, Post-Translational Receptor, Cannabinoid, CB1 - deficiency Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - physiology Spatial Memory - physiology URB597 URB597 mitogen-activated protein kinase CREB fatty acid amide hydrolase CB1 null mice CaMKIV phosphorylation anandamide long-term potentiation
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