A Novel Tool for Detecting Amyloid Deposits in Systemic Amyloidosis In Vitro and In Vivo

We synthesized (trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB) and used this compound to detect amyloid fibrils in autopsy and biopsy samples from patients with localized amyloidosis, such as familial prion disease, and systemic amyloidosis, such as familial amyloidoti...

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Bibliographic Details
Published in:	Laboratory investigation Vol. 83; no. 12; pp. 1751 - 1759
Main Authors:	Ando, Yukio, Haraoka, Katsuki, Terazaki, Hisayasu, Tanoue, Yutaka, Ishikawa, Kensuke, Katsuragi, Shoichi, Nakamura, Masaaki, Sun, Xuguo, Nakagawa, Kazuko, Sasamoto, Kazumi, Takesako, Kazuhiro, Ishizaki, Takashi, Sasaki, Yutaka, Doh-ura, Katsumi
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-12-2003 Nature Publishing Nature Publishing Group
Subjects:	Adult Amyloid - analysis Amyloid - metabolism Amyloid - ultrastructure Amyloidosis Amyloidosis - diagnosis Amyloidosis - metabolism Amyloidosis - pathology Animals Biological and medical sciences Congo Red - chemistry Disease Models, Animal Female Humans Immunohistochemistry In Vitro Techniques Male Medical sciences Metabolic diseases Mice Middle Aged Other metabolic disorders Prealbumin - metabolism Prealbumin - ultrastructure Staining and Labeling - methods Styrenes - chemistry Styrenes - metabolism Human Nervous system diseases Prion disease Clinical form Metabolic diseases Exploration Light peptide chain Polyneuropathy Enzymopathy In vitro Protein Infection In vivo Autopsy Biopsy Amyloid protein AA Clinical biology Amyloidosis Peripheral nerve disease Technique
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