Stimulation of Airway Mucin Gene Expression by Interleukin (IL)-17 through IL-6 Paracrine/Autocrine Loop

Mucus hypersecretion and persistent airway inflammation are common features of various airway diseases, such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. One key question is: does the associated airway inflammation in these diseases affect mucus production? If so, what is t...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 278; no. 19; pp. 17036 - 17043
Main Authors:	Chen, Yin, Thai, Philip, Zhao, Yu-Hua, Ho, Ye-Shih, DeSouza, Mary M., Wu, Reen
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 09-05-2003 American Society for Biochemistry and Molecular Biology
Subjects:	Animals Autocrine Communication Gene Expression Regulation - drug effects Haplorhini Humans Interleukin-17 - pharmacology Interleukin-6 - pharmacology Interleukin-6 - physiology Mice Mice, Transgenic Mucin 5AC Mucin-5B Mucins - biosynthesis Mucins - genetics Paracrine Communication Respiratory Mucosa - drug effects Respiratory Mucosa - physiology
Online Access:	Get full text
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