Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors

• Published in: Scientific reports Vol. 11; no. 1; p. 12226
• Main Authors: Maanaoui, Mehdi, Provôt, François, Bouyé, Sébastien, Lionet, Arnaud, Lenain, Rémi, Fages, Victor, Frimat, Marie, Lebas, Céline, Glowacki, François, Hazzan, Marc
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09-06-2021; Nature Publishing Group; Nature Portfolio
• Series: Scientific Reports
• Subjects: 692/4022; 692/4022/272; Anuria; Calcineurin; Calcineurin inhibitors; Creatinine; Graft rejection; Grafts; Humanities and Social Sciences; Immunosuppressive agents; Kidney transplantation; Life Sciences; Medical prognosis; multidisciplinary; Multivariate analysis; Organ donors; Renal failure; Renal function; Risk groups; Science; Science (multidisciplinary); Survival
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-91843-7

As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in such population. 116 kidney recipients from deceased kidney donors over 70 years were included from 2005 to 2015 in a single-center retrospective study. IRF before organ procurement was defined as a serum creatinine above 1.0 mg/dl or a transient episode of oligo-anuria. Mean ages for donors and recipients were respectively 74.8 ± 3.5 and 66.7 ± 8.0. Graft survival censored for death at 5 years was of 77%. Using a multivariate analysis by Cox model, the only predictor of graft loss present in the donor was IRF before organ procurement (HR 4.2 CI95[1.8–9.7]). IRF was also associated with significant lower estimated glomerular filtration rates up to 1 year post-transplantation. By contrast, KDPI score (median of 98 [96–100]), was not associated with the risk of graft failure. Then, IRF before kidney procurement may define a risk subgroup among very-old deceased kidney donors, in whom pre-implantatory biopsies, dual kidney transplantation or calcineurin inhibitor-free immunosuppressive regimen could help to improve outcomes.