Pioglitazone Improves Aortic Wall Elasticity in a Rat Model of Elastocalcinotic Arteriosclerosis

Specific treatment of age-related aortic wall arteriosclerosis and stiffening is lacking. Because ligands for peroxisome proliferator–activated receptor γ have beneficial effects on the arterial wall in atherosclerosis, via an antiinflammatory mechanism, we investigated whether long-term pioglitazon...

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Bibliographic Details
Published in:	Hypertension (Dallas, Tex. 1979) Vol. 46; no. 2; pp. 372 - 379
Main Authors:	Gaillard, Virginie, Casellas, Daniel, Seguin-Devaux, Carole, Schohn, Hervé, Dauça, Michel, Atkinson, Jeffrey, Lartaud, Isabelle
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Heart Association, Inc 01-08-2005 Hagerstown, MD Lippincott
Subjects:	Animals Aorta - pathology Aorta - physiopathology Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aortic Diseases - pathology Aortic Diseases - physiopathology Arterial hypertension. Arterial hypotension Arteriosclerosis - pathology Arteriosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Calcinosis - pathology Calcinosis - physiopathology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cytokines - metabolism Elastic Tissue - pathology Elastic Tissue - physiopathology Elasticity Experimental diseases Hypertrophy, Left Ventricular - pathology Macrophages - pathology Male Medical sciences Monocytes - pathology Myocardium - pathology Organ Size - drug effects PPAR gamma - metabolism Rats Rats, Wistar Thiazolidinediones - pharmacology Immunohistochemistry Nuclear receptor Calcium Rat Elasticity Cardiovascular disease Inorganic element Vascular disease Alkaloid Hypoglycemic agent arteriosclerosis Atherosclerosis Aorta Extracellular matrix Stiffness peroxisome proliferator-activated receptor Vascular wall Elastic modulus pulse pressure Monocyte Pioglitazone Rodentia Antiinflammatory agent Interleukin 1β Thiazolidinedione derivatives Stress Left ventricle Vertebrata Mammalia Treatment Tumor necrosis factor Animal Calcification Elastic fiber Infiltration Comparative study Macrophage Nicotine
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