Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study

• Published in: Neuroscience Vol. 250; pp. 364 - 371
• Main Authors: Haller, S, Rodriguez, C, Moser, D, Toma, S, Hofmeister, J, Sinanaj, I, Van De Ville, D, Giannakopoulos, P, Lovblad, K.-O
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 10-10-2013; Elsevier
• Subjects: Aged; Aged, 80 and over; aging; Biological and medical sciences; BOLD; Brain - drug effects; caffeine; Caffeine - pharmacology; Central Nervous System Stimulants - pharmacology; Cerebrovascular Circulation - drug effects; cognition; Cross-Over Studies; Double-Blind Method; Female; fMRI; Fundamental and applied biological sciences. Psychology; Humans; Image Processing, Computer-Assisted; Linear Models; Magnetic Resonance Imaging; Male; Medical sciences; Memory, Short-Term - drug effects; Middle Aged; Neural Pathways - drug effects; Neurology; Neuropharmacology; Oxygen - blood; Pharmacology. Drug treatments; Principal Component Analysis; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychomotor Performance - drug effects; Psychopharmacology; Spin Labels; Vertebrates: nervous system and sense organs; pre-frontal cortex; blood oxygen level dependent; CBF; vPMC; independent components; GLM; ventral premotor cortex; PFC; arterial spin labeling; CDR; caffeine; working memory; WM; ICs; ASL; BOLD; Clinical Dementia Rating scale; FSL; tensorial-independent component analysis; FMRIB’s Software Library; cognition; SMA; general linear model; MEG; fMRI; supplementary motor area; TICA; DTI; cerebral blood flow; diffusion tensor imaging; aging; magnetoencephalography; functional magnetic resonance imaging; Senescence; CNS stimulant; Psychotropic; Acute; Central nervous system; Cognition; Nuclear magnetic resonance imaging; Encephalon; Working memory; Caffeine; Functional imaging
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.07.021

Highlights • Caffeine enhances task-related BOLD activation and functional connectivity in the elderly. • Task-related BOLD activation enhancement predominates in the striatum. • Functional connectivity increases in working memory-related networks by 8.2%. • Caffeine reduces baseline perfusion by 23% (global vasoconstriction).