Multifactorial Determinants of Protein Expression in Prokaryotic Open Reading Frames

A quantitative description of the relationship between protein expression levels and open reading frame (ORF) nucleotide sequences is important for understanding natural systems, designing synthetic systems, and optimizing heterologous expression. Codon identity, mRNA secondary structure, and nucleo...

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Bibliographic Details
Published in:	Journal of molecular biology Vol. 402; no. 5; pp. 905 - 918
Main Authors:	Allert, Malin, Cox, J. Colin, Hellinga, Homme W.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 08-10-2010
Subjects:	5' Untranslated Regions Bacteria - genetics Bacteria - metabolism Bacterial Proteins - biosynthesis Base Composition Codon codon usage Computational Biology - methods Escherichia coli Gene Expression Genes, Synthetic Models, Theoretical mRNA secondary structure Nucleic Acid Conformation nucleotide composition Open Reading Frames Protein Biosynthesis protein expression RNA, Bacterial - genetics RNA, Messenger - genetics synthetic genes nucleotide composition ORF MS LC CAI TnT mRNA secondary structure synthetic genes protein expression codon usage
Online Access:	Get full text
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