Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses

• Published in: International journal of molecular sciences Vol. 24; no. 15; p. 12028
• Main Authors: Cano-Vicent, Alba, Tuñón-Molina, Alberto, Martí, Miguel, Serrano-Aroca, Ángel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27-07-2023; MDPI
• Subjects: Acetic acid; Acids; antiviral activity; Antiviral agents; Biocompatibility; Chitin; chitosan; Communication; cytoxicity; Drug approval; enveloped viruses; Influenza; Molecular weight; non-enveloped viruses; Organic acids; Severe acute respiratory syndrome coronavirus 2; Toxicity; Viral infections; Viruses; Spain; United States > US; chitosan; cytoxicity; enveloped viruses; non-enveloped viruses; antiviral activity; acetic acid
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms241512028

Chitosan films were prepared by solvent casting using an acetic acid-based solution. The films that were developed contained 15.49% of acetic acid solution (10%
/
) and showed biocompatibility in vitro in human keratinocyte HaCaT cells and potent antiviral activity against both enveloped and non-enveloped viruses. The results showed up to 99.98% and 99.92% viral inactivation against the phi 6 enveloped bacteriophage and MS2 non-enveloped bacteriophage, respectively, suggesting that this chitosan/acetic acid film is a promising material for biomedical applications that require biodegradable broad-spectrum antiviral materials.