Adenovirus-Mediated Delivery of Decoy Hyper Binding Sites Targeting Oncogenic HMGA1 Reduces Pancreatic and Liver Cancer Cell Viability

High mobility group AT-hook 1 (HMGA1) protein is an oncogenic architectural transcription factor that plays an essential role in early development, but it is also implicated in many human cancers. Elevated levels of HMGA1 in cancer cells cause misregulation of gene expression and are associated with...

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Bibliographic Details
Published in:	Molecular therapy. Oncolytics Vol. 8; pp. 52 - 61
Main Authors:	Hassan, Faizule, Ni, Shuisong, Arnett, Tyler C., McKell, Melanie C., Kennedy, Michael A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 30-03-2018 Elsevier Limited American Society of Gene & Cell Therapy Elsevier
Subjects:	adenovirus Adenoviruses Apoptosis Binding sites Cancer therapies cancer therapy Cell growth Cell proliferation Cell viability Chemoresistance Chemotherapy chemotherapy resistance Cyclin-dependent kinases decoy binding site Deoxyribonucleic acid DNA DNA repair Gemcitabine Gene expression Genomes Hepatocytes high mobility group A protein High mobility group proteins HMGA1 Infections Kinases Liver cancer MicroRNAs neoadjuvant therapy oncogenic transcription factor Pancreas Pancreatic cancer Proteins Replication Transcription factors Tumor cell lines cancer therapy chemotherapy resistance pancreatic cancer adenovirus HMGA1 decoy binding site high mobility group A protein liver cancer oncogenic transcription factor neoadjuvant therapy
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