Control of residues of thyreostats in slaughter animals in Poland in 2011–2017

In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples...

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Published in:Journal of veterinary research Vol. 62; no. 4; pp. 511 - 517
Main Authors: Woźniak, Barbara, Matraszek-Żuchowska, Iwona, Sielska, Katarzyna, Witek, Sebastian, Posyniak, Andrzej, Niemczuk, Krzysztof, Żmudzki, Jan
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Published: Poland Sciendo 01-12-2018
De Gruyter Poland
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Abstract In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011–2017. The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method. In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants. : The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.
AbstractList Introduction: In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011–2017. Material and Methods: The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method. Results: In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants. Conclusions : The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.
Introduction: In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011–2017.
In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011–2017. The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method. In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants. : The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.
In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011-2017. The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method. In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants. The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.
Introduction: In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011–2017.Material and Methods: The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method.Results: In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants.Conclusions: The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.
Author Posyniak, Andrzej
Witek, Sebastian
Żmudzki, Jan
Woźniak, Barbara
Matraszek-Żuchowska, Iwona
Niemczuk, Krzysztof
Sielska, Katarzyna
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  organization: Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30729210$$D View this record in MEDLINE/PubMed
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10.3724/SP.J.1123.2017.05004
10.1016/j.aca.2008.08.027
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10.1021/jf504475f
10.1016/S0003-2670(02)00753-5
10.1080/01652176.1982.9693830
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10.1080/19440049.2010.544681
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10.2478/v10213-012-0108-z
10.1016/j.aca.2011.02.021
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Issue 4
Keywords thiouracil
monitoring
urine
thyreostats
Language English
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Snippet In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For...
Introduction: In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive...
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StartPage 511
SubjectTerms Abattoirs
Animals
Drinking water
Farms
Liquid chromatography
Mass spectroscopy
monitoring
Propylthiouracil
Slaughter
thiouracil
thyreostats
Urine
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Title Control of residues of thyreostats in slaughter animals in Poland in 2011–2017
URI http://www.degruyter.com/doi/10.2478/jvetres-2018-0077
https://www.ncbi.nlm.nih.gov/pubmed/30729210
https://www.proquest.com/docview/2545238551
https://pubmed.ncbi.nlm.nih.gov/PMC6364168
https://doaj.org/article/40de9aa621ae4a5088490187d66d5e31
Volume 62
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