Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors
Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Design Retrospective cohort study. Setting University-affiliated institution. Patient(s) Fort...
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| Published in: | Fertility and sterility Vol. 102; no. 2; pp. 394 - 398 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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01-08-2014
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| Abstract | Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Design Retrospective cohort study. Setting University-affiliated institution. Patient(s) Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013. Intervention(s) None. Main Outcome Measure(s) Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities. Result(s) Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%. Conclusion(s) Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities. |
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| AbstractList | OBJECTIVETo test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH).DESIGNRetrospective cohort study.SETTINGUniversity-affiliated institution.PATIENT(S)Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013.INTERVENTION(S)None.MAIN OUTCOME MEASURE(S)Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities.RESULT(S)Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%.CONCLUSION(S)Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities. To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Retrospective cohort study. University-affiliated institution. Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013. None. Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities. Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%. Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities. Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Design Retrospective cohort study. Setting University-affiliated institution. Patient(s) Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013. Intervention(s) None. Main Outcome Measure(s) Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities. Result(s) Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%. Conclusion(s) Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities. |
| Author | Vega, Mario, M.D Moshier, Erin L., M.S Keltz, Martin D., M.D Breborowicz, Andrzej, M.D., Ph.D McGovern, Peter G., M.D |
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| Cites_doi | 10.1093/molehr/gaq039 10.1016/S0140-6736(89)91723-6 10.1016/j.placenta.2011.07.009 10.1016/j.fertnstert.2005.04.068 10.1093/humrep/den217 10.1093/humrep/13.11.3151 10.1016/j.fertnstert.2013.04.039 10.1016/j.fertnstert.2008.07.1761 10.1093/humrep/deh536 10.1016/j.fertnstert.2012.01.104 10.1016/S1472-6483(12)60073-X 10.1016/j.fertnstert.2013.04.035 10.1016/j.rbmo.2012.10.021 10.1016/j.fertnstert.2013.04.043 10.1093/humrep/des394 10.1007/s10815-012-9918-4 10.1093/humrep/deh094 10.1056/NEJMoa067744 10.1016/S0015-0282(03)00605-8 10.1016/j.fertnstert.2010.04.003 10.1159/000086904 10.1093/humrep/deq139 10.1016/j.fertnstert.2010.09.010 10.1093/humrep/den287 10.1016/j.fertnstert.2009.09.055 10.1093/humrep/15.8.1781 10.1016/j.fertnstert.2013.02.056 10.1055/s-0032-1313908 10.1002/pd.1773 10.1093/humrep/den400 10.1093/oxfordjournals.humrep.a137192 10.1007/s10815-013-0070-6 |
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| Keywords | embryo quality Aneuploidy assisted reproduction preimplantation genetic screening PGS |
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| References | Rubio, Rodrigo, Mercader, Mateu, Buendia, Pehlivan (bib5) 2007; 27 Hardarson, Hanson, Lundin, Hillensjo, Nilsson, Stevic (bib14) 2008; 23 Verlinsky, Ginsberg, Lifchez, Valle, Moise, Strom (bib10) 1990; 5 Mastenbroek, Twisk, van Echten-Arends, Sikkema-Raddatz, Korevaar, Verhoeve (bib15) 2007; 357 Handyside, Pattinson, Penketh, Delhanty, Winston, Tuddenham (bib9) 1989; 1 Machtinger, Racowsky (bib1) 2013; 26 De Boer, McArthur, Murray, Jansen (bib11) 2002; 4 Li, DeUgarte, Surrey, Danzer, DeCherney, Hill (bib19) 2005; 84 Werlin, Rodi, DeCherney, Marello, Hill, Munne (bib17) 2003; 80 Keltz, Vega, Sirota, Lederman, Moshier, Gonzales (bib26) 2013; 30 Forman, Hong, Ferry, Tao, Taylor, Levy (bib31) 2013; 100 Alfarawati, Fragouli, Colls, Stevens, Gutierrez-Mateo, Schoolcraft (bib6) 2011; 95 Fritz (bib13) 2008; 23 Baart, Van Opstal, Los, Fauser, Martini (bib22) 2004; 19 Santos, Teklenburg, Macklon, Van Opstal, Schuring-Blom, Krijtenburg (bib3) 2010; 25 Scott, Ferry, Su, Tao, Scott, Treff (bib28) 2012; 97 Forman, Upham, Cheng, Zhao, Hong, Treff (bib7) 2013; 100 Treff, Levy, Su, Northrop, Tao, Scott (bib23) 2010; 16 Scott, Upham, Forman, Zhao, Treff (bib32) 2013; 100 Scott, Upham, Forman, Hong, Scott, Taylor (bib27) 2013; 100 Magli, Jones, Gras, Gianaroli, Korman, Trounson (bib4) 2000; 15 Fishel, Gordon, Lynch, Dowell, Ndukwe, Kelada (bib29) 2010; 93 Capalbo, Bono, Spizzichino, Biricik, Baldi, Colamaria (bib24) 2013; 28 Fragouli, Lenzi, Ross, Katz-Jaffe, Schoolcraft, Wells (bib8) 2008; 23 Staessen, Platteau, Van Assche, Michiels, Tournaye, Camus (bib16) 2004; 19 Evsikov, Verlinsky (bib18) 1998; 13 Mir, Rodrigo, Mercader, Buendia, Mateu, Milan-Sanchez (bib30) 2013; 30 Munné (bib20) 2005; 111 Montag, Liebenthron, Koster (bib2) 2011; 32 Gutierrez-Mateo, Colls, Sanchez-Garcia, Escudero, Prates, Ketterson (bib25) 2011; 95 Barbash-Hazan, Frumkin, Malcov, Yaron, Cohen, Azem (bib21) 2009; 92 Fragouli, Wells (bib12) 2012; 30 Keltz (10.1016/j.fertnstert.2014.04.026_bib26) 2013; 30 Capalbo (10.1016/j.fertnstert.2014.04.026_bib24) 2013; 28 Machtinger (10.1016/j.fertnstert.2014.04.026_bib1) 2013; 26 Scott (10.1016/j.fertnstert.2014.04.026_bib28) 2012; 97 Fragouli (10.1016/j.fertnstert.2014.04.026_bib12) 2012; 30 Fritz (10.1016/j.fertnstert.2014.04.026_bib13) 2008; 23 Montag (10.1016/j.fertnstert.2014.04.026_bib2) 2011; 32 Forman (10.1016/j.fertnstert.2014.04.026_bib7) 2013; 100 Scott (10.1016/j.fertnstert.2014.04.026_bib27) 2013; 100 Fragouli (10.1016/j.fertnstert.2014.04.026_bib8) 2008; 23 De Boer (10.1016/j.fertnstert.2014.04.026_bib11) 2002; 4 Fishel (10.1016/j.fertnstert.2014.04.026_bib29) 2010; 93 Scott (10.1016/j.fertnstert.2014.04.026_bib32) 2013; 100 Staessen (10.1016/j.fertnstert.2014.04.026_bib16) 2004; 19 Munné (10.1016/j.fertnstert.2014.04.026_bib20) 2005; 111 Verlinsky (10.1016/j.fertnstert.2014.04.026_bib10) 1990; 5 Treff (10.1016/j.fertnstert.2014.04.026_bib23) 2010; 16 Magli (10.1016/j.fertnstert.2014.04.026_bib4) 2000; 15 Rubio (10.1016/j.fertnstert.2014.04.026_bib5) 2007; 27 Mir (10.1016/j.fertnstert.2014.04.026_bib30) 2013; 30 Hardarson (10.1016/j.fertnstert.2014.04.026_bib14) 2008; 23 Mastenbroek (10.1016/j.fertnstert.2014.04.026_bib15) 2007; 357 Barbash-Hazan (10.1016/j.fertnstert.2014.04.026_bib21) 2009; 92 Handyside (10.1016/j.fertnstert.2014.04.026_bib9) 1989; 1 Forman (10.1016/j.fertnstert.2014.04.026_bib31) 2013; 100 Baart (10.1016/j.fertnstert.2014.04.026_bib22) 2004; 19 Santos (10.1016/j.fertnstert.2014.04.026_bib3) 2010; 25 Gutierrez-Mateo (10.1016/j.fertnstert.2014.04.026_bib25) 2011; 95 Alfarawati (10.1016/j.fertnstert.2014.04.026_bib6) 2011; 95 Evsikov (10.1016/j.fertnstert.2014.04.026_bib18) 1998; 13 Li (10.1016/j.fertnstert.2014.04.026_bib19) 2005; 84 Werlin (10.1016/j.fertnstert.2014.04.026_bib17) 2003; 80 |
| References_xml | – volume: 100 start-page: 100 year: 2013 end-page: 107.e1 ident: bib31 article-title: In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial publication-title: Fertil Steril contributor: fullname: Levy – volume: 95 start-page: 520 year: 2011 end-page: 524 ident: bib6 article-title: The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender publication-title: Fertil Steril contributor: fullname: Schoolcraft – volume: 80 start-page: 467 year: 2003 end-page: 468 ident: bib17 article-title: Preimplantation genetic diagnosis as both a therapeutic and diagnostic tool in assisted reproductive technology publication-title: Fertil Steril contributor: fullname: Munne – volume: 23 start-page: 2806 year: 2008 end-page: 2812 ident: bib14 article-title: Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trial publication-title: Hum Reprod contributor: fullname: Stevic – volume: 93 start-page: 1006.e7 year: 2010 end-page: 1006.e10 ident: bib29 article-title: Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF? publication-title: Fertil Steril contributor: fullname: Kelada – volume: 84 start-page: 1395 year: 2005 end-page: 1400 ident: bib19 article-title: Fluorescence in situ hybridization reanalysis of day-6 human blastocysts diagnosed with aneuploidy on day 3 publication-title: Fertil Steril contributor: fullname: Hill – volume: 26 start-page: 210 year: 2013 end-page: 221 ident: bib1 article-title: Morphological systems of human embryo assessment and clinical evidence publication-title: Reprod Biomed Online contributor: fullname: Racowsky – volume: 23 start-page: 2596 year: 2008 end-page: 2608 ident: bib8 article-title: Comprehensive molecular cytogenetic analysis of the human blastocyst stage publication-title: Hum Reprod contributor: fullname: Wells – volume: 100 start-page: 718 year: 2013 end-page: 724 ident: bib7 article-title: Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer publication-title: Fertil Steril contributor: fullname: Treff – volume: 4 start-page: 35 year: 2002 ident: bib11 article-title: First live birth following blastocyst biopsy and PGD analysis publication-title: Reprod Biomed Online contributor: fullname: Jansen – volume: 13 start-page: 3151 year: 1998 end-page: 3155 ident: bib18 article-title: Mosaicism in the inner cell mass of human blastocysts publication-title: Hum Reprod contributor: fullname: Verlinsky – volume: 100 start-page: 697 year: 2013 end-page: 703 ident: bib27 article-title: Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial publication-title: Fertil Steril contributor: fullname: Taylor – volume: 27 start-page: 748 year: 2007 end-page: 756 ident: bib5 article-title: Impact of chromosomal abnormalities on preimplantation embryo development publication-title: Prenat Diag contributor: fullname: Pehlivan – volume: 15 start-page: 1781 year: 2000 end-page: 1786 ident: bib4 article-title: Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro publication-title: Hum Reprod contributor: fullname: Trounson – volume: 100 start-page: 624 year: 2013 end-page: 630 ident: bib32 article-title: Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial publication-title: Fertil Steril contributor: fullname: Treff – volume: 30 start-page: 1333 year: 2013 end-page: 1339 ident: bib26 article-title: Preimplantation genetic screening (PGS) with comparative genomic hybridization (CGH) following day 3 single cell blastomere biopsy markedly improves IVF outcomes while lowering multiple pregnancies and miscarriages publication-title: J Assist Reprod Genet contributor: fullname: Gonzales – volume: 16 start-page: 583 year: 2010 end-page: 589 ident: bib23 article-title: SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH publication-title: Mol Hum Reprod contributor: fullname: Scott – volume: 5 start-page: 826 year: 1990 end-page: 829 ident: bib10 article-title: Analysis of the first polar body: preconception genetic diagnosis publication-title: Hum Reprod contributor: fullname: Strom – volume: 1 start-page: 347 year: 1989 end-page: 349 ident: bib9 article-title: Biopsy of human preimplantation embryos and sexing by DNA amplification publication-title: Lancet contributor: fullname: Tuddenham – volume: 30 start-page: 143 year: 2013 end-page: 149 ident: bib30 article-title: False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3 publication-title: J Assist Reprod Genet contributor: fullname: Milan-Sanchez – volume: 28 start-page: 509 year: 2013 end-page: 518 ident: bib24 article-title: Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development publication-title: Hum Reprod contributor: fullname: Colamaria – volume: 95 start-page: 953 year: 2011 end-page: 958 ident: bib25 article-title: Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos publication-title: Fertil Steril contributor: fullname: Ketterson – volume: 92 start-page: 890 year: 2009 end-page: 896 ident: bib21 article-title: Preimplantation aneuploid embryos undergo self-correction in correlation with their developmental potential publication-title: Fertil Steril contributor: fullname: Azem – volume: 25 start-page: 1916 year: 2010 end-page: 1926 ident: bib3 article-title: The fate of the mosaic embryo: chromosomal constitution and development of day 4, 5 and 8 human embryos publication-title: Hum Reprod contributor: fullname: Krijtenburg – volume: 19 start-page: 685 year: 2004 end-page: 693 ident: bib22 article-title: Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5 publication-title: Hum Reprod contributor: fullname: Martini – volume: 357 start-page: 9 year: 2007 end-page: 17 ident: bib15 article-title: In vitro fertilization with preimplantation genetic screening publication-title: N Engl J Med contributor: fullname: Verhoeve – volume: 30 start-page: 289 year: 2012 end-page: 301 ident: bib12 article-title: Aneuploidy screening for embryo selection publication-title: Semin Reprod Med contributor: fullname: Wells – volume: 19 start-page: 2849 year: 2004 end-page: 2858 ident: bib16 article-title: Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial publication-title: Hum Reprod contributor: fullname: Camus – volume: 111 start-page: 305 year: 2005 end-page: 309 ident: bib20 article-title: Analysis of chromosome segregation during preimplantation genetic diagnosis in both male and female translocation heterozygotes publication-title: Cytogenet Genome Res contributor: fullname: Munné – volume: 97 start-page: 870 year: 2012 end-page: 875 ident: bib28 article-title: Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study publication-title: Fertil Steril contributor: fullname: Treff – volume: 23 start-page: 2617 year: 2008 end-page: 2621 ident: bib13 article-title: Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now? publication-title: Hum Reprod contributor: fullname: Fritz – volume: 32 start-page: S252 year: 2011 end-page: S256 ident: bib2 article-title: Which morphological scoring system is relevant in human embryo development? publication-title: Placenta contributor: fullname: Koster – volume: 16 start-page: 583 year: 2010 ident: 10.1016/j.fertnstert.2014.04.026_bib23 article-title: SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH publication-title: Mol Hum Reprod doi: 10.1093/molehr/gaq039 contributor: fullname: Treff – volume: 1 start-page: 347 year: 1989 ident: 10.1016/j.fertnstert.2014.04.026_bib9 article-title: Biopsy of human preimplantation embryos and sexing by DNA amplification publication-title: Lancet doi: 10.1016/S0140-6736(89)91723-6 contributor: fullname: Handyside – volume: 32 start-page: S252 issue: Suppl 3 year: 2011 ident: 10.1016/j.fertnstert.2014.04.026_bib2 article-title: Which morphological scoring system is relevant in human embryo development? publication-title: Placenta doi: 10.1016/j.placenta.2011.07.009 contributor: fullname: Montag – volume: 84 start-page: 1395 year: 2005 ident: 10.1016/j.fertnstert.2014.04.026_bib19 article-title: Fluorescence in situ hybridization reanalysis of day-6 human blastocysts diagnosed with aneuploidy on day 3 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2005.04.068 contributor: fullname: Li – volume: 23 start-page: 2806 year: 2008 ident: 10.1016/j.fertnstert.2014.04.026_bib14 article-title: Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trial publication-title: Hum Reprod doi: 10.1093/humrep/den217 contributor: fullname: Hardarson – volume: 13 start-page: 3151 year: 1998 ident: 10.1016/j.fertnstert.2014.04.026_bib18 article-title: Mosaicism in the inner cell mass of human blastocysts publication-title: Hum Reprod doi: 10.1093/humrep/13.11.3151 contributor: fullname: Evsikov – volume: 100 start-page: 624 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib32 article-title: Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.04.039 contributor: fullname: Scott – volume: 92 start-page: 890 year: 2009 ident: 10.1016/j.fertnstert.2014.04.026_bib21 article-title: Preimplantation aneuploid embryos undergo self-correction in correlation with their developmental potential publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2008.07.1761 contributor: fullname: Barbash-Hazan – volume: 19 start-page: 2849 year: 2004 ident: 10.1016/j.fertnstert.2014.04.026_bib16 article-title: Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial publication-title: Hum Reprod doi: 10.1093/humrep/deh536 contributor: fullname: Staessen – volume: 97 start-page: 870 year: 2012 ident: 10.1016/j.fertnstert.2014.04.026_bib28 article-title: Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2012.01.104 contributor: fullname: Scott – volume: 4 start-page: 35 issue: Suppl 2 year: 2002 ident: 10.1016/j.fertnstert.2014.04.026_bib11 article-title: First live birth following blastocyst biopsy and PGD analysis publication-title: Reprod Biomed Online doi: 10.1016/S1472-6483(12)60073-X contributor: fullname: De Boer – volume: 100 start-page: 697 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib27 article-title: Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.04.035 contributor: fullname: Scott – volume: 26 start-page: 210 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib1 article-title: Morphological systems of human embryo assessment and clinical evidence publication-title: Reprod Biomed Online doi: 10.1016/j.rbmo.2012.10.021 contributor: fullname: Machtinger – volume: 100 start-page: 718 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib7 article-title: Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.04.043 contributor: fullname: Forman – volume: 28 start-page: 509 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib24 article-title: Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development publication-title: Hum Reprod doi: 10.1093/humrep/des394 contributor: fullname: Capalbo – volume: 30 start-page: 143 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib30 article-title: False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3 publication-title: J Assist Reprod Genet doi: 10.1007/s10815-012-9918-4 contributor: fullname: Mir – volume: 19 start-page: 685 year: 2004 ident: 10.1016/j.fertnstert.2014.04.026_bib22 article-title: Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5 publication-title: Hum Reprod doi: 10.1093/humrep/deh094 contributor: fullname: Baart – volume: 357 start-page: 9 year: 2007 ident: 10.1016/j.fertnstert.2014.04.026_bib15 article-title: In vitro fertilization with preimplantation genetic screening publication-title: N Engl J Med doi: 10.1056/NEJMoa067744 contributor: fullname: Mastenbroek – volume: 80 start-page: 467 year: 2003 ident: 10.1016/j.fertnstert.2014.04.026_bib17 article-title: Preimplantation genetic diagnosis as both a therapeutic and diagnostic tool in assisted reproductive technology publication-title: Fertil Steril doi: 10.1016/S0015-0282(03)00605-8 contributor: fullname: Werlin – volume: 95 start-page: 520 year: 2011 ident: 10.1016/j.fertnstert.2014.04.026_bib6 article-title: The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2010.04.003 contributor: fullname: Alfarawati – volume: 111 start-page: 305 year: 2005 ident: 10.1016/j.fertnstert.2014.04.026_bib20 article-title: Analysis of chromosome segregation during preimplantation genetic diagnosis in both male and female translocation heterozygotes publication-title: Cytogenet Genome Res doi: 10.1159/000086904 contributor: fullname: Munné – volume: 25 start-page: 1916 year: 2010 ident: 10.1016/j.fertnstert.2014.04.026_bib3 article-title: The fate of the mosaic embryo: chromosomal constitution and development of day 4, 5 and 8 human embryos publication-title: Hum Reprod doi: 10.1093/humrep/deq139 contributor: fullname: Santos – volume: 95 start-page: 953 year: 2011 ident: 10.1016/j.fertnstert.2014.04.026_bib25 article-title: Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2010.09.010 contributor: fullname: Gutierrez-Mateo – volume: 23 start-page: 2596 year: 2008 ident: 10.1016/j.fertnstert.2014.04.026_bib8 article-title: Comprehensive molecular cytogenetic analysis of the human blastocyst stage publication-title: Hum Reprod doi: 10.1093/humrep/den287 contributor: fullname: Fragouli – volume: 93 start-page: 1006.e7 year: 2010 ident: 10.1016/j.fertnstert.2014.04.026_bib29 article-title: Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF? publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2009.09.055 contributor: fullname: Fishel – volume: 15 start-page: 1781 year: 2000 ident: 10.1016/j.fertnstert.2014.04.026_bib4 article-title: Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro publication-title: Hum Reprod doi: 10.1093/humrep/15.8.1781 contributor: fullname: Magli – volume: 100 start-page: 100 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib31 article-title: In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.02.056 contributor: fullname: Forman – volume: 30 start-page: 289 year: 2012 ident: 10.1016/j.fertnstert.2014.04.026_bib12 article-title: Aneuploidy screening for embryo selection publication-title: Semin Reprod Med doi: 10.1055/s-0032-1313908 contributor: fullname: Fragouli – volume: 27 start-page: 748 year: 2007 ident: 10.1016/j.fertnstert.2014.04.026_bib5 article-title: Impact of chromosomal abnormalities on preimplantation embryo development publication-title: Prenat Diag doi: 10.1002/pd.1773 contributor: fullname: Rubio – volume: 23 start-page: 2617 year: 2008 ident: 10.1016/j.fertnstert.2014.04.026_bib13 article-title: Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now? publication-title: Hum Reprod doi: 10.1093/humrep/den400 contributor: fullname: Fritz – volume: 5 start-page: 826 year: 1990 ident: 10.1016/j.fertnstert.2014.04.026_bib10 article-title: Analysis of the first polar body: preconception genetic diagnosis publication-title: Hum Reprod doi: 10.1093/oxfordjournals.humrep.a137192 contributor: fullname: Verlinsky – volume: 30 start-page: 1333 year: 2013 ident: 10.1016/j.fertnstert.2014.04.026_bib26 article-title: Preimplantation genetic screening (PGS) with comparative genomic hybridization (CGH) following day 3 single cell blastomere biopsy markedly improves IVF outcomes while lowering multiple pregnancies and miscarriages publication-title: J Assist Reprod Genet doi: 10.1007/s10815-013-0070-6 contributor: fullname: Keltz |
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| Snippet | Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with... To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with... OBJECTIVETo test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with... |
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| SubjectTerms | Adult Aneuploidy assisted reproduction Biopsy Blastocyst - pathology Chromosome Aberrations Cleavage Stage, Ovum Comparative Genomic Hybridization embryo quality Female Fertilization in Vitro - adverse effects Genetic Testing - methods Humans Internal Medicine Linear Models Obstetrics and Gynecology PGS Ploidies Pregnancy Preimplantation Diagnosis - methods preimplantation genetic screening Retrospective Studies Risk Factors |
| Title | Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors |
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