Tumorigenesis Mediated by an Antigen Receptor

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 89; no. 18; pp. 8482 - 8486
• Main Authors: Jack, Hans-Martin, Beck-Engeser, Gabriele, Lee, Gary, Wofsy, David, Wabl, Matthias
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 15-09-1992; National Acad Sciences; National Academy of Sciences
• Subjects: Animals; Antibodies; Antigen receptors; Antigens; Antigens, Viral - immunology; B lymphocytes; Base Sequence; Biological and medical sciences; Cell Division; Cell growth; Cell lines; Cells; Cellular biology; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, B-Lymphocyte, Light Chain; Genes, Immunoglobulin; Hematologic and hematopoietic diseases; Immunoglobulin Variable Region - genetics; Immunoglobulins; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, B-Cell - microbiology; Lymphoma, B-Cell - pathology; Medical sciences; Mice; Molecular Sequence Data; Receptors, Antigen, B-Cell - physiology; Retroviridae - immunology; Tumors; Viruses; Immunoglobulins; Pathogenesis; heavy-Peptide chain; Variable region; Rodentia; Retroviridae; Molecular interaction; Malignant hemopathy; B-Lymphocyte; Carcinogenesis; Lymphoma; IgM; Virus; Antigen; Vertebrata; Experimental disease; Membrane receptor; Mammalia; Endogenous; Mouse
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.89.18.8482

The heavy chain variable region of the immunoglobulin receptors on cells of the B lymphoma NYC are almost identical to that of other independent B-cell tumors of B/W mice. NYC IgM binds a viral antigen produced by the tumor cells; and despite extensive screening, immunoglobulin-negative variants were never found in the NYC cells, suggesting that NYC loses the capacity to grow in culture when it does not synthesize surface immunoglobulin. These findings indicate that the interaction of endogenous antigen with surface IgM continuously stimulates growth and, thus, that the tumorigenesis of B lymphomas in B/W mice is mediated by antigen receptors.