Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties

• Published in: Polymers Vol. 15; no. 12; p. 2752
• Main Authors: Fernández, Katherina, Llanquileo, Aylen, Bustos, Monserrat, Aedo, Valentina, Ruiz, Isleidy, Carrasco, Sebastián, Tapia, Mauricio, Pereira, Miguel, Meléndrez, Manuel F, Aguayo, Claudio, Atanase, Leonard I
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-06-2023; MDPI
• Subjects: Biomedical materials; Care and treatment; Cellulose; Chemical composition; Composite materials; Enzymes; Ethanol; Graphene; graphene oxide; Graphite; Mechanical properties; nanocellulose; Pharmaceutical industry; Physiological aspects; Physiology; polydopamine; Polymerization; reduced graphene oxide; Self-assembly; Surface charge; Tannins; Thermodynamic properties; Toxicity; Wound healing; Wounds and injuries; X ray photoelectron spectroscopy; Chile; United States; Germany; graphene oxide; nanocellulose; wound healing; polydopamine; reduced graphene oxide
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym15122752

In this study, a conductive composite material, based on graphene oxide (GO), nanocellulose (CNF), and tannins (TA) from pine bark, reduced using polydopamine (PDA), was developed for wound dressing. The amount of CNF and TA was varied in the composite material, and a complete characterization including SEM, FTIR, XRD, XPS, and TGA was performed. Additionally, the conductivity, mechanical properties, cytotoxicity, and in vitro wound healing of the materials were evaluated. A successful physical interaction between CNF, TA, and GO was achieved. Increasing CNF amount in the composite reduced the thermal properties, surface charge, and conductivity, but its strength, cytotoxicity, and wound healing performance were improved. The TA incorporation slightly reduced the cell viability and migration, which may be associated with the doses used and the extract's chemical composition. However, the in-vitro-obtained results demonstrated that these composite materials can be suitable for wound healing.