Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders

Background Rare DNA breakage repair disorders predispose to infection and lymphoreticular malignancies. Hematopoietic cell transplantation (HCT) is curative, but coadministered chemotherapy or radiotherapy is damaging because of systemic radiosensitivity. We collected HCT outcome data for Nijmegen b...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 141; no. 1; pp. 322 - 328.e10
Main Authors:	Slack, James, MD, Albert, Michael H., MD, Balashov, Dmitry, PhD, Belohradsky, Bernd H., MD, Bertaina, Alice, PhD, Bleesing, Jack, PhD, Booth, Claire, PhD, Buechner, Jochen, PhD, Buckley, Rebecca H., MD, Ouachée-Chardin, Marie, MD, Deripapa, Elena, MD, Drabko, Katarzyna, MD, Eapen, Mary, MD, Feuchtinger, Tobias, MD, Finocchi, Andrea, PhD, Gaspar, H. Bobby, PhD, Ghosh, Sujal, MD, Gillio, Alfred, MD, Gonzalez-Granado, Luis I., MD, Grunebaum, Eyal, MD, Güngör, Tayfun, MD, Heilmann, Carsten, MD, Helminen, Merja, PhD, Higuchi, Kohei, MD, Imai, Kohsuke, PhD, Kalwak, Krzysztof, MD, Kanazawa, Nubuo, PhD, Karasu, Gülsün, MD, Kucuk, Zeynep Y., MD, Laberko, Alexandra, MD, Lange, Andrzej, MD, Mahlaoui, Nizar, MD, Meisel, Roland, MD, Moshous, D., PhD, Muramatsu, Hideki, PhD, Parikh, Suhag, MD, Pasic, Srdjan, PhD, Schmid, Irene, MD, Schuetz, Catharina, PhD, Schulz, Ansgar, MD, Schultz, Kirk R., MD, Shaw, Peter J., MD, Slatter, Mary A., MD, Sykora, Karl-Walter, PhD, Tamura, Shinobu, PhD, Taskinen, Mervi, MD, Wawer, Angela, MD, Wolska-Kuśnierz, Beata, PhD, Cowan, Morton J., MD, Fischer, Alain, PhD, Gennery, Andrew R., MD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-01-2018 Elsevier Limited
Subjects:	Alkylation Allergy and Immunology Anemia Antigens Ataxia Ataxia telangiectasia Bone marrow Bone marrow transplantation Cell cycle Cernunnos-XLF deficiency Chemotherapy Complications Conditioning Consortia Cyclophosphamide Deoxyribonucleic acid DNA DNA damage DNA ligase (ATP) DNA ligase IV deficiency DNA repair DNA repair disorders Double-strand break repair Graft-versus-host reaction hematopoietic stem cell transplantation Immunodeficiency Immunological tolerance Immunology Infections Kinases Lymphocytes Malignancy Mortality Mutation Nijmegen breakage syndrome Patients Proteins Radiation therapy Radiosensitivity Stem cell transplantation Stem cells Transplantation Transplants & implants Severe combined immunodeficiency Nijmegen breakage syndrome Nonhomologous end-joining factor 1 DNA repair disorders SCID Anti-thymocyte globulin Chronic graft-versus-host disease Hematopoietic cell transplantation aGvHD hematopoietic stem cell transplantation PTLD Recombination-activating gene Reduced-intensity conditioning Myeloablative conditioning NBS NHEJ1 Graft-versus-host disease GvHD LIG4 Nonhomologous end-joining DNA double-strand break RIC DNA ligase IV deficiency MAC Cernunnos-XLF deficiency Cernunnos-XLF Cernunnos–XRCC4-like factor Ataxia-telangiectasia AT ATG Ataxia-telangiectasia mutated Natural killer DNA-dsb Acute graft-versus-host disease HCT Posttransplantation lymphoproliferative disorder RAG ATM cGvHD NHEJ NK
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!