Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation

• Published in: FEBS open bio Vol. 3; no. 1; pp. 341 - 345
• Main Authors: Kim, Yoon Hee, Yoshimoto, Miki, Nakayama, Kazuko, Tanino, Sousuke, Fujimura, Yoshinori, Yamada, Koji, Tachibana, Hirofumi
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01-01-2013; John Wiley & Sons, Inc; Elsevier
• Subjects: Acids; Allergic diseases; Asthma; Cancer; Cytokines; Diabetes; Disease; Food allergies; Glucose; IgE; Immunoglobulin E; Immunoglobulins; Kinases; Ovalbumin; Pentagalloylglucose; Phosphorylation; Recombination; Signal transducers and activators of transcription6; Signal transduction; Stat6 protein; Tannic acid; Transcription activation; ɛ Germline transcript; United States > US; Tannic acid; ɛGT; IL; IgE; PGG; Signal transducers and activators of transcription6; IFN-γ; STAT; JAK; ɛ Germline transcript; TGF-β; OVA; Pentagalloylglucose; IgE, immunoglobulin E; STAT, signal transducer and activator of transcription; ɛGT, ɛ germline transcript; PGG, 1,2,3,4,6-penta-O-galloyl-β-d-glucose; TGF-β, transforming growth factor-beta; JAK, Janus kinase; IL, interleukin; OVA, ovalbumin; IFN-γ, interferon-gamma
• ISSN: 2211-5463; 2211-5463
• DOI: 10.1016/j.fob.2013.07.008

Interleukin (IL)-4 is a critical stimulator that induces ɛ germline transcripts (ɛGT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL-4-induced ɛGT expression. PGG exerted its inhibitory function by suppressing IL-4-induced activation of IL-4Rα, JAK3 and STAT6. Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin-induced IgE production in vivo by inhibiting IL-4-induced ɛGT expression and the IL-4 signaling pathway. In conclusion, our results suggest that tannic acid may attenuate allergic diseases by suppressing IgE production by inhibiting IL-4-induced signaling.
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•Tannic acid (TA) is highly galloylated pentagalloylglucose derived from oriental herbs.•Germline transcript (GT) expression is indispensable for immunoglobulin (Ig) E class switching.•PGG and TA inhibit ɛGT expression by attenuating IL-4 signaling.•TA attenuates ovalbumin-induced IgE production in vivo.