Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells

Germline mutations in the Exostoses-1 gene (EXT1) are found in hereditary multiple exostoses syndrome, which is characterized by the formation of osteochondromas and an increased risk of chondrosarcomas and osteosarcomas. However, despite its putative tumor-suppressor function, little is known of th...

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Published in:	Human molecular genetics Vol. 13; no. 22; pp. 2753 - 2765
Main Authors:	Ropero, Santiago, Setien, Fernando, Espada, Jesus, Fraga, Mario F., Herranz, Michel, Asp, Julia, Benassi, Maria Serena, Franchi, Alessandro, Patiño, Ana, Ward, Laura S., Bovee, Judith, Cigudosa, Juan C., Wim, Wuyts, Esteller, Manel
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 15-11-2004 Oxford Publishing Limited (England)
Subjects:	Acute Animals Antineoplastic Agents Antineoplastic Agents - therapeutic use Biological and medical sciences biosynthesis Cell Line Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes CpG Islands deficiency DNA Methylation drug therapy Epigenesis Epigenesis, Genetic Experimental Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Expression Regulation, Neoplastic - genetics Gene Silencing Genes Genes, Tumor Suppressor Genetic genetics Genetics of eukaryotes. Biological and molecular evolution Heparitin Sulfate Heparitin Sulfate - biosynthesis Heparitin Sulfate - deficiency Heterologous Humans Leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - metabolism Lymphocytic MEDICAL AND HEALTH SCIENCES MEDICIN OCH HÄLSOVETENSKAP metabolism Mice Mice, Nude Missense Molecular and cellular biology Mutation Mutation, Missense N-Acetylglucosaminyltransferases N-Acetylglucosaminyltransferases - biosynthesis N-Acetylglucosaminyltransferases - genetics Neoplasms Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neoplastic Nude pathology Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Promoter Regions (Genetics) Promoter Regions, Genetic Promyelocytic Skin Neoplasms Skin Neoplasms - genetics Skin Neoplasms - metabolism therapeutic use Transplantation Transplantation, Heterologous Tretinoin Tretinoin - therapeutic use Tumor Tumor Suppressor Epigenetics Genetics Malignant tumor Sulfates Tumor suppressor gene
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