Variants of 3T3 Cells Lacking Mitogenic Response to Epidermal Growth Factor
We have previously demonstrated that epidermal growth factor (EGF) can serve as a potent mitogen for 3T3 cells. We have now selected variant 3T3 cell lines unable to respond to EGF, in order to define cellular events unique to the EGF response and to distinguish which of these events are necessary a...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS Vol. 74; no. 9; pp. 3918 - 3921 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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United States
National Academy of Sciences of the United States of America
01-09-1977
National Acad Sciences |
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| Abstract | We have previously demonstrated that epidermal growth factor (EGF) can serve as a potent mitogen for 3T3 cells. We have now selected variant 3T3 cell lines unable to respond to EGF, in order to define cellular events unique to the EGF response and to distinguish which of these events are necessary and which are merely correlative to mitogenesis. By simultaneously treating cells with EGF and colchicine, we eliminated those cells stimulated by EGF to enter mitosis. Of the eight clonal EGF nonresponder variants selected by this procedure, none retains a functional EGF receptor. The EGF nonresponsive variant lines still retain the ability to respond to other mitogens. |
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| AbstractList | We have previously demonstrated that epidermal growth factor (EGF) can serve as a potent mitogen for 3T3 cells. We have now selected variant 3T3 cell lines unable to respond to EGF, in order to define cellular events unique to the EGF response and to distinguish which of these events are necessary and which are merely correlative to mitogenesis. By simultaneously treating cells with EGF and colchicine, we eliminated those cells stimulated by EGF to enter mitosis. Of the eight clonal EGF nonresponder variants selected by this procedure, none retains a functional EGF receptor. The EGF nonresponsive va-riant lines still retain the ability to respond to other mitogens. We have previously demonstrated that epidermal growth factor (EGF) can serve as a potent mitogen for 3T3 cells. We have now selected variant 3T3 cell lines unable to respond to EGF, in order to define cellular events unique to the EGF response and to distinguish which of these events are necessary and which are merely correlative to mitogenesis. By simultaneously treating cells with EGF and colchicine, we eliminated those cells stimulated by EGF to enter mitosis. Of the eight clonal EGF nonresponder variants selected by this procedure, none retains a functional EGF receptor. The EGF nonresponsive variant lines still retain the ability to respond to other mitogens. |
| Author | Pruss, Rebecca M. Herschman, Harvey R. |
| Author_xml | – sequence: 1 givenname: Rebecca M. surname: Pruss fullname: Pruss, Rebecca M. – sequence: 2 givenname: Harvey R. surname: Herschman fullname: Herschman, Harvey R. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/302945$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | 3T3 cells Cell division Cell Division - drug effects Cell growth Cell Line Cell lines Cells Colchicine - pharmacology Cultured cells Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Insulin Insulin - pharmacology Kinetics Mitogens Mutation Peptides - pharmacology Prostaglandins F - pharmacology Receptors Swiss 3T3 cells Tetradecanoylphorbol Acetate - pharmacology |
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| Title | Variants of 3T3 Cells Lacking Mitogenic Response to Epidermal Growth Factor |
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