EEG source analysis of epileptiform activity using a 1 mm anisotropic hexahedra finite element head model

• Published in: NeuroImage (Orlando, Fla.) Vol. 44; no. 2; pp. 399 - 410
• Main Authors: Rullmann, M., Anwander, A., Dannhauer, M., Warfield, S.K., Duffy, F.H., Wolters, C.H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15-01-2009; Elsevier Limited
• Subjects: Anisotropy; Brain; Brain - physiopathology; Brain Mapping - methods; Cerebrospinal fluid; Child; Computer Simulation; Diagnosis, Computer-Assisted - methods; Diffusion-tensor magnetic resonance imaging; Electroencephalography; Electroencephalography - methods; Epilepsy; Epilepsy - diagnosis; Epilepsy - physiopathology; Finite Element Analysis; Finite element method; Geometry; Goal function scan; Humans; Male; Minimum norm least squares; Models, Neurological; NMR; Nuclear magnetic resonance; Presurgical epilepsy diagnosis; Reproducibility of Results; Sensitivity and Specificity; Source analysis; Spatio-temporal dipole modeling; Standardized low resolution electromagnetic tomography; Studies; Surface- and intra-cranial EEG; Tissue conductivity anisotropy; Finite element method; Standardized low resolution electromagnetic tomography; Spatio-temporal dipole modeling; Goal function scan; Diffusion-tensor magnetic resonance imaging; Source analysis; Tissue conductivity anisotropy; Surface- and intra-cranial EEG; Minimum norm least squares; Cerebrospinal fluid; Presurgical epilepsy diagnosis
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2008.09.009

The major goal of the evaluation in presurgical epilepsy diagnosis for medically intractable patients is the precise reconstruction of the epileptogenic foci, preferably with non-invasive methods. This paper evaluates whether surface electroencephalography (EEG) source analysis based on a 1 mm anisotropic finite element (FE) head model can provide additional guidance for presurgical epilepsy diagnosis and whether it is practically feasible in daily routine. A 1 mm hexahedra FE volume conductor model of the patient's head with special focus on accurately modeling the compartments skull, cerebrospinal fluid (CSF) and the anisotropic conducting brain tissues was constructed using non-linearly co-registered T1-, T2- and diffusion-tensor-magnetic resonance imaging data. The electrodes of intra-cranial EEG (iEEG) measurements were extracted from a co-registered computed tomography image. Goal function scan (GFS), minimum norm least squares (MNLS), standardized low resolution electromagnetic tomography (sLORETA) and spatio-temporal current dipole modeling inverse methods were then applied to the peak of the averaged ictal discharges EEG data. MNLS and sLORETA pointed to a single center of activity. Moving and rotating single dipole fits resulted in an explained variance of more than 97%. The non-invasive EEG source analysis methods localized at the border of the lesion and at the border of the iEEG electrodes which mainly received ictal discharges. Source orientation was towards the epileptogenic tissue. For the reconstructed superficial source, brain conductivity anisotropy and the lesion conductivity had only a minor influence, whereas a correct modeling of the highly conducting CSF compartment and the anisotropic skull was found to be important. The proposed FE forward modeling approach strongly simplifies meshing and reduces run-time (37 ms for one forward computation in the model with 3.1 million unknowns), corroborating the practical feasibility of the approach.