Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury

Abstract Objectives We recently reported that administration of atrial natriuretic peptide during the perioperative period has prophylactic effects with respect to not only cardiovascular but also respiratory complications following pulmonary resection. However, its mechanisms are not well understoo...

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Bibliographic Details
Published in:	Pulmonary pharmacology & therapeutics Vol. 29; no. 1; pp. 24 - 30
Main Authors:	Nojiri, Takashi, Hosoda, Hiroshi, Tokudome, Takeshi, Miura, Koichi, Ishikane, Shin, Kimura, Toru, Shintani, Yasushi, Inoue, Masayoshi, Sawabata, Noriyoshi, Miyazato, Mikiya, Okumura, Meinoshin, Kangawa, Kenji
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-2014
Subjects:	Acute lung injury Acute Lung Injury - prevention & control Animals Atrial Natriuretic Factor - pharmacology Atrial natriuretic peptide Bronchoalveolar Lavage Fluid Disease Models, Animal E-Selectin - genetics Endothelial Cells - drug effects Endothelial Cells - metabolism Humans Interleukin-6 - metabolism Lipopolysaccharides - toxicity Lung - cytology Lung - drug effects Lung - pathology Medical Education Mice Mice, Inbred C57BL Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary inflammation Pulmonary/Respiratory Tumor Necrosis Factor-alpha - metabolism Up-Regulation - drug effects CINC-1 MCP-1 ANP MIP-2 monocyte chemoattractant protein-1 Atrial natriuretic peptide HPAEC MPO interleukin-6 LPS mitogen-activated protein kinase tumor necrosis factor-alpha NF-κB macrophage inflammatory protein-2 Pulmonary inflammation hematoxylin–eosin Acute lung injury cytokine-induced neutrophil chemoattractant-1 VEGF nuclear factor-kappa B guanylyl cyclase-A myeloperoxidase MAPK BAL human pulmonary artery endothelial cells IL-6 GC-A TNF-α vascular endothelial growth factor lipopolysaccharide bronchoalveolar lavage HE
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