Chalcones and Gastrointestinal Cancers: Experimental Evidence

• Published in: International journal of molecular sciences Vol. 24; no. 6; p. 5964
• Main Authors: Michalkova, Radka, Kello, Martin, Cizmarikova, Martina, Bardelcikova, Annamaria, Mirossay, Ladislav, Mojzis, Jan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-03-2023; MDPI
• Subjects: angiogenesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Biocompatibility; Cancer; Care and treatment; Cell cycle; Cell death; Cell growth; Cell Line, Tumor; Cell proliferation; chalcones; Chalcones - chemistry; Chalcones - pharmacology; Chalcones - therapeutic use; Chemotherapy; Colorectal cancer; Cytochrome; Development and progression; Drug resistance; Evaluation; Gastric cancer; Gastrointestinal cancer; Gastrointestinal Neoplasms - drug therapy; Humans; Neoplasm Recurrence, Local; Plants; Polyphenols; Proteins; Radiation therapy; Review; signaling pathway; Stomach cancer; Toxicity; chalcones; multidrug resistance; colorectal cancer; Helicobacter pylori; cell death; gastric cancer; inflammation; angiogenesis; reactive oxygen species; signaling pathway
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24065964

Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers with a high incidence rate worldwide. The current treatment including surgery, chemotherapy or radiotherapy has several limitations such as drug toxicity, cancer recurrence or drug resistance and thus it is a great challenge to discover an effective and safe therapy for CRC and GC. In the last decade, numerous phytochemicals and their synthetic analogs have attracted attention due to their anticancer effect and low organ toxicity. Chalcones, plant-derived polyphenols, received marked attention due to their biological activities as well as for relatively easy structural manipulation and synthesis of new chalcone derivatives. In this study, we discuss the mechanisms by which chalcones in both in vitro and in vivo conditions suppress cancer cell proliferation or cancer formation.