Synthesis of a glycodendrimer incorporating multiple mannosides on a glucoside core

The synthesis of a glycodendrimer by incorporating repetitive mannoside units onto a glucoside core was carried out to multivalently probe fundamental carbohydrate–protein interactions. The dendritic structure was constructed by a modified procedure that utilized multiple glycosylations between a th...

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Bibliographic Details
Published in:	Canadian journal of chemistry Vol. 89; no. 8; pp. 959 - 963
Main Authors:	Wang, Chao, Sanders, Brian, Baker, David C
Format:	Journal Article
Language:	English
Published:	Ottawa NRC Research Press 01-08-2011 Canadian Science Publishing NRC Research Press
Subjects:	carbohydrate Carbohydrates Chemical synthesis dendrimer Dendrimers dendrimère Dendritic structure Glucosides Glycosylation hydrate de carbone Hydrates Mannose Molecular structure multivalence multivalency Properties Proteins Synthesis United States China
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Summary:	The synthesis of a glycodendrimer by incorporating repetitive mannoside units onto a glucoside core was carried out to multivalently probe fundamental carbohydrate–protein interactions. The dendritic structure was constructed by a modified procedure that utilized multiple glycosylations between a thioether glycosyl donor and five elongated spacer arms of a glycosyl acceptor. The completed dendrimer bears a full carbohydrate structure, and thus should find its potential application in the study of mannose–lectin interactions.
ISSN:	0008-4042 1480-3291
DOI:	10.1139/v11-069