Quantitative Susceptibility Mapping and Amide Proton Transfer-Chemical Exchange Saturation Transfer for the Evaluation of Intracerebral Hemorrhage Model
This study aimed to evaluate an intracerebral hemorrhage (ICH) model using quantitative susceptibility mapping (QSM) and chemical exchange saturation transfer (CEST) with preclinical 7T-magnetic resonance imaging (MRI) and determine the potential of amide proton transfer-CEST (APT-CEST) for use as a...
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| Published in: | International journal of molecular sciences Vol. 24; no. 7; p. 6627 |
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| Language: | English |
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| Abstract | This study aimed to evaluate an intracerebral hemorrhage (ICH) model using quantitative susceptibility mapping (QSM) and chemical exchange saturation transfer (CEST) with preclinical 7T-magnetic resonance imaging (MRI) and determine the potential of amide proton transfer-CEST (APT-CEST) for use as a biomarker for the early detection of ICH. Six Wistar male rats underwent MRI, and another six underwent histopathological examinations on postoperative days 0, 3, and 7. The ICH model was created by injecting bacterial collagenase into the right hemisphere of the brain. QSM and APT-CEST MRI were performed using horizontal 7T-MRI. Histological studies were performed to observe ICH and detect iron deposition at the ICH site. T
-weighted images (T
WI) revealed signal changes associated with hemoglobin degeneration in red blood cells, indicating acute-phase hemorrhage on day 0, late-subacute-phase hemorrhage on day 3, and chronic-phase hemorrhage on day 7. The susceptibility alterations in each phase were detected using QSM. QSM and Berlin blue staining revealed hemosiderin deposition in the chronic phase. APT-CEST revealed high magnetization transfer ratios in the acute phase. Abundant mobile proteins and peptides were observed in early ICH, which were subsequently diluted. APT-CEST imaging may be a reliable noninvasive biomarker for the early diagnosis of ICH. |
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| AbstractList | This study aimed to evaluate an intracerebral hemorrhage (ICH) model using quantitative susceptibility mapping (QSM) and chemical exchange saturation transfer (CEST) with preclinical 7T-magnetic resonance imaging (MRI) and determine the potential of amide proton transfer-CEST (APT-CEST) for use as a biomarker for the early detection of ICH. Six Wistar male rats underwent MRI, and another six underwent histopathological examinations on postoperative days 0, 3, and 7. The ICH model was created by injecting bacterial collagenase into the right hemisphere of the brain. QSM and APT-CEST MRI were performed using horizontal 7T-MRI. Histological studies were performed to observe ICH and detect iron deposition at the ICH site. T
2
-weighted images (T
2
WI) revealed signal changes associated with hemoglobin degeneration in red blood cells, indicating acute-phase hemorrhage on day 0, late-subacute-phase hemorrhage on day 3, and chronic-phase hemorrhage on day 7. The susceptibility alterations in each phase were detected using QSM. QSM and Berlin blue staining revealed hemosiderin deposition in the chronic phase. APT-CEST revealed high magnetization transfer ratios in the acute phase. Abundant mobile proteins and peptides were observed in early ICH, which were subsequently diluted. APT-CEST imaging may be a reliable noninvasive biomarker for the early diagnosis of ICH. This study aimed to evaluate an intracerebral hemorrhage (ICH) model using quantitative susceptibility mapping (QSM) and chemical exchange saturation transfer (CEST) with preclinical 7T-magnetic resonance imaging (MRI) and determine the potential of amide proton transfer-CEST (APT-CEST) for use as a biomarker for the early detection of ICH. Six Wistar male rats underwent MRI, and another six underwent histopathological examinations on postoperative days 0, 3, and 7. The ICH model was created by injecting bacterial collagenase into the right hemisphere of the brain. QSM and APT-CEST MRI were performed using horizontal 7T-MRI. Histological studies were performed to observe ICH and detect iron deposition at the ICH site. T2-weighted images (T2WI) revealed signal changes associated with hemoglobin degeneration in red blood cells, indicating acute-phase hemorrhage on day 0, late-subacute-phase hemorrhage on day 3, and chronic-phase hemorrhage on day 7. The susceptibility alterations in each phase were detected using QSM. QSM and Berlin blue staining revealed hemosiderin deposition in the chronic phase. APT-CEST revealed high magnetization transfer ratios in the acute phase. Abundant mobile proteins and peptides were observed in early ICH, which were subsequently diluted. APT-CEST imaging may be a reliable noninvasive biomarker for the early diagnosis of ICH. This study aimed to evaluate an intracerebral hemorrhage (ICH) model using quantitative susceptibility mapping (QSM) and chemical exchange saturation transfer (CEST) with preclinical 7T-magnetic resonance imaging (MRI) and determine the potential of amide proton transfer-CEST (APT-CEST) for use as a biomarker for the early detection of ICH. Six Wistar male rats underwent MRI, and another six underwent histopathological examinations on postoperative days 0, 3, and 7. The ICH model was created by injecting bacterial collagenase into the right hemisphere of the brain. QSM and APT-CEST MRI were performed using horizontal 7T-MRI. Histological studies were performed to observe ICH and detect iron deposition at the ICH site. T[sub.2]-weighted images (T[sub.2]WI) revealed signal changes associated with hemoglobin degeneration in red blood cells, indicating acute-phase hemorrhage on day 0, late-subacute-phase hemorrhage on day 3, and chronic-phase hemorrhage on day 7. The susceptibility alterations in each phase were detected using QSM. QSM and Berlin blue staining revealed hemosiderin deposition in the chronic phase. APT-CEST revealed high magnetization transfer ratios in the acute phase. Abundant mobile proteins and peptides were observed in early ICH, which were subsequently diluted. APT-CEST imaging may be a reliable noninvasive biomarker for the early diagnosis of ICH. This study aimed to evaluate an intracerebral hemorrhage (ICH) model using quantitative susceptibility mapping (QSM) and chemical exchange saturation transfer (CEST) with preclinical 7T-magnetic resonance imaging (MRI) and determine the potential of amide proton transfer-CEST (APT-CEST) for use as a biomarker for the early detection of ICH. Six Wistar male rats underwent MRI, and another six underwent histopathological examinations on postoperative days 0, 3, and 7. The ICH model was created by injecting bacterial collagenase into the right hemisphere of the brain. QSM and APT-CEST MRI were performed using horizontal 7T-MRI. Histological studies were performed to observe ICH and detect iron deposition at the ICH site. T -weighted images (T WI) revealed signal changes associated with hemoglobin degeneration in red blood cells, indicating acute-phase hemorrhage on day 0, late-subacute-phase hemorrhage on day 3, and chronic-phase hemorrhage on day 7. The susceptibility alterations in each phase were detected using QSM. QSM and Berlin blue staining revealed hemosiderin deposition in the chronic phase. APT-CEST revealed high magnetization transfer ratios in the acute phase. Abundant mobile proteins and peptides were observed in early ICH, which were subsequently diluted. APT-CEST imaging may be a reliable noninvasive biomarker for the early diagnosis of ICH. |
| Audience | Academic |
| Author | Sawaya, Reika Ueda, Junpei Saito, Shigeyoshi |
| AuthorAffiliation | 1 Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita 560-0871, Osaka, Japan; u010443b@ecs.osaka-u.ac.jp (R.S.); uedaj@sahs.med.osaka-u.ac.jp (J.U.) 2 Department of Advanced Medical Technologies, National Cardiovascular and Cerebral Research Center, Suita 564-8565, Osaka, Japan |
| AuthorAffiliation_xml | – name: 1 Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita 560-0871, Osaka, Japan; u010443b@ecs.osaka-u.ac.jp (R.S.); uedaj@sahs.med.osaka-u.ac.jp (J.U.) – name: 2 Department of Advanced Medical Technologies, National Cardiovascular and Cerebral Research Center, Suita 564-8565, Osaka, Japan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37047596$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_2196_56484 crossref_primary_10_1016_j_mri_2023_07_014 crossref_primary_10_3390_biomedicines11092348 |
| Cites_doi | 10.1016/j.mri.2019.07.005 10.1161/01.STR.27.12.2312 10.1016/j.neuroimage.2011.08.082 10.1016/S1474-4422(12)70104-7 10.3171/jns.1994.80.1.0051 10.1080/00207454.2019.1576659 10.1038/srep45696 10.1161/STROKEAHA.119.027037 10.1002/nbm.4710 10.1002/mrm.24315 10.1259/bjr.20181016 10.1161/STROKEAHA.113.001638 10.3390/diagnostics12051046 10.1259/bjr.20220304 10.1006/jmre.1999.1956 10.1148/radiol.2018171918 10.1007/s12194-019-00510-0 10.1038/nm907 10.1002/jmri.26645 10.1002/nbm.3367 10.1002/jmri.25143 10.2174/1872208313666181217112745 10.1002/nbm.3283 10.3390/cancers14081907 10.1002/mrm.25690 10.1016/j.brainres.2007.04.077 10.1002/jmri.25957 10.1148/radiology.189.1.8372185 10.1002/jmri.24768 10.1016/j.mri.2022.06.010 10.1007/s11883-012-0252-1 10.1002/jmri.25397 10.1161/STROKEAHA.110.594457 10.1002/jmri.25838 10.1002/nbm.3054 10.1111/j.1552-6569.2012.00751.x 10.1002/mrm.21873 10.1016/S1474-4422(08)70041-3 10.1109/TMI.2011.2182523 |
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| Keywords | intracerebral hemorrhage amide proton transfer quantitative susceptibility mapping preclinical 7T-MRI chemical exchange saturation transfer |
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| Title | Quantitative Susceptibility Mapping and Amide Proton Transfer-Chemical Exchange Saturation Transfer for the Evaluation of Intracerebral Hemorrhage Model |
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