Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review

MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs about 19 to 22 nucleotides in length, that have been reported to have important roles in the control of bone development. MiRNAs have a strong influence on osteoblast differentiation through stages of lineage comm...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 24; no. 7; p. 6423
Main Authors:	Loh, Hui-Yi, Norman, Brendan P, Lai, Kok-Song, Cheng, Wan-Hee, Nik Abd Rahman, Nik Mohd Afizan, Mohamed Alitheen, Noorjahan Banu, Osman, Mohd Azuraidi
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 29-03-2023 MDPI
Subjects:	Apoptosis BMPs bone Bone growth Bone morphogenetic proteins Bone Morphogenetic Proteins - metabolism Bone turnover Bones Cbfa-1 protein Cell cycle Cell differentiation Cell Differentiation - genetics Cell signaling Cellular signal transduction Differentiation (biology) Drug development Enzymes Gene expression Genes Genetic aspects Genetic transcription Growth factors Hedgehog protein Hedgehog Proteins - metabolism Homeostasis MicroRNA MicroRNAs microRNAs (miRNAs) MicroRNAs - genetics MicroRNAs - metabolism miRNA Nucleotides osteoblast lineage Osteoblastogenesis Osteoblasts Osteoblasts - metabolism Osteogenesis Osteogenesis - genetics Post-transcription Proteins Review RNA polymerase Signal Transduction Smads Stem cells TGF-βs Transcription factors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factor-b Transforming growth factors Wnt protein β-Catenin BMPs Smads osteogenic differentiation microRNAs (miRNAs) bone bone diseases TGF-βs osteoblast lineage
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