Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midline

In vertebrates, spinal commissural axons project along a transverse path toward and across the floor plate (FP). Post-crossing commissural axons alter their responsiveness to FP-associated guidance cues and turn to project longitudinally in a fasciculated manner prior to extending away from the midl...

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Bibliographic Details
Published in:	Molecular and cellular neuroscience Vol. 36; no. 4; pp. 462 - 471
Main Authors:	Imondi, Ralph, Jevince, Angela R., Helms, Amy W., Johnson, Jane E., Kaprielian, Zaven
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2007
Subjects:	Altered responsiveness Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation - physiology Commissural axon Cues Fasciculation Floor plate Functional Laterality - physiology Gene Expression Regulation, Developmental - genetics Gene Targeting - methods Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Growth Cones - metabolism Growth Cones - ultrastructure Math1 Mice Mice, Transgenic Neural Cell Adhesion Molecule L1 - genetics Neural Cell Adhesion Molecule L1 - metabolism Neural Pathways - cytology Neural Pathways - embryology Neural Pathways - metabolism Spinal Cord - cytology Spinal Cord - embryology Spinal Cord - metabolism tau Proteins - genetics tau Proteins - metabolism Up-Regulation - physiology Math1 Floor plate Commissural axon L1 Altered responsiveness Fasciculation
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