Exosomes in Colorectal Cancer: From Physiology to Clinical Applications

• Published in: International journal of molecular sciences Vol. 24; no. 5; p. 4382
• Main Authors: Titu, Stefan, Gata, Vlad Alexandru, Decea, Roxana Maria, Mocan, Teodora, Dina, Constantin, Irimie, Alexandru, Lisencu, Cosmin Ioan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23-02-2023; MDPI
• Subjects: Angiogenesis; Antigens; B cells; Biomarkers; Biomarkers, Tumor - genetics; Bone marrow; Breast cancer; Cancer; Cancer therapies; Chemoresistance; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - pathology; Communication; Dendritic cells; Development and progression; Diagnosis; exosomal miRNA; exosome; Exosomes; Exosomes - metabolism; Fibroblasts; Health aspects; Health services; Humans; Immunomodulation; Intracellular signalling; Kinases; Leukemia; lncRNA; Metabolites; Metastases; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Mitochondrial DNA; Patients; Peptides; Physiological aspects; Prevention; Proteins; Review; Signal Transduction; Tumors; Vaccines; Romania; exosomal miRNA; cancer; colorectal cancer; lncRNA; exosome
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24054382

Exosomes are nanosized vesicles that have been found to be involved in many diseases. Exosomes can mediate communication between cells in a variety of ways. Certain types of mediators derived from cancer cells can play a crucial role in the development of this pathology, promoting tumor growth, invasion, metastasis, angiogenesis, and immunomodulation. Exosomes in the bloodstream show promise as a future tool for detecting cancer at an early stage. The sensitivity and specificity of clinical exosome biomarkers need to be enhanced. Knowledge of exosomes is not only important for understanding the significance of cancer progression but also for providing clinicians with useful information for the diagnosis, treatment, and discovery of methods to prevent cancer from recurring. The widespread adoption of diagnostic tools based on exosomes may revolutionize cancer diagnosis and treatment. Tumor metastasis, chemoresistance, and immunity are all aided by exosomes. A potential new approach to cancer therapy involves preventing metastasis by inhibiting miRNA intracellular signaling and blocking the formation of pre-metastatic niches. For colorectal patients, exosomes represent a promising area of investigation for improving the diagnosis, treatment, and management. Reported data demonstrate that the serum expression level of certain exosomal miRNA is significantly higher in primary colorectal cancer patients. The present review discusses mechanisms and clinical implications of exosomes in colorectal cancer.