Impact of long‐lasting spontaneous physical activity on bone morphogenetic protein 4 in the heart and tibia in murine model of heart failure

Bone morphogenetic protein 4 (BMP4) plays an important role in bone remodeling and in heart failure pathogenesis. The aim of this study was to evaluate the effect of spontaneous physical activity on the expression of BMP4 in the heart and tibia of the transgenic (Tgαq*44) mice, representing a model...

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Bibliographic Details
Published in:	Physiological reports Vol. 8; no. 8; pp. e14412 - n/a
Main Authors:	Majerczak, Joanna, Filipowska, Joanna, Tylko, Grzegorz, Guzik, Magdalena, Karasinski, Janusz, Piechowicz, Ewa, Pyza, Elżbieta, Chlopicki, Stefan, Zoladz, Jerzy A.
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-04-2020 John Wiley and Sons Inc Wiley
Subjects:	Animal models Animals Apoptosis BMP4 Bone morphogenetic protein 4 Bone Morphogenetic Protein 4 - metabolism Bone remodeling Bones Calcification, Physiologic Calcium Cardiac function Cardiomegaly - metabolism Cardiovascular Conditions, Disorders and Treatments Congestive heart failure Disease Models, Animal Disease Progression Endurance and Performance Ethics Exercise Female Growth factors Heart Heart failure Heart Failure - metabolism Heart Failure - therapy Hypertrophy Immunoblotting Mice Mice, Transgenic Motor Activity - physiology Muscle Physiology Myocardium - metabolism Original Oxidative stress Phosphorus Physical activity Physical Conditioning, Animal - physiology Physical fitness Proteins Signalling Pathways Tibia Tibia - metabolism Transgenic animals Transgenic mice Wheel running Poland BMP4 heart failure physical activity
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