Alginate Oligosaccharides Repair Liver Injury by Improving Anti-Inflammatory Capacity in a Busulfan-Induced Mouse Model

• Published in: International journal of molecular sciences Vol. 24; no. 4; p. 3097
• Main Authors: Hao, Yanan, Fang, Hanhan, Yan, Xiaowei, Shen, Wei, Liu, Jing, Han, Pengfei, Zhao, Yong, Zhang, Weidong, Feng, Yanni
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-02-2023; MDPI
• Subjects: Alcoholics; Alginates; Alginates - pharmacology; Alginic acid; Animals; Anti-Inflammatory Agents; Anti-inflammatory drugs; Antioxidants; AOS; blood metabolites; Body weight; Busulfan; Cell growth; Cytokines; Disease Models, Animal; Epidemiology; Gene expression; Inflammation; Liver; Liver cirrhosis; Liver diseases; Metabolism; Metabolites; Mice; Oligosaccharides; Oligosaccharides - pharmacology; Oxidative stress; Proteins; Resveratrol; Sinuses; Tumor necrosis factor-TNF; China; blood metabolites; liver diseases; AOS; inflammation
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24043097

Liver diseases are associated with many factors, including medicines and alcoholics, which have become a global problem. It is crucial to overcome this problem. Liver diseases always come with inflammatory complications, which might be a potential target to deal with this issue. Alginate oligosaccharides (AOS) have been demonstrated to have many beneficial effects, especially anti-inflammation. In this study, 40 mg/kg body weight (BW) of busulfan was intraperitoneally injected once, and then the mice were dosed with ddH
O or AOS 10 mg/kg BW every day by oral gavage for five weeks. We investigated AOS as a potential no-side-effect and low-cost therapy for liver diseases. For the first time, we discovered that AOS 10 mg/kg recovered liver injury by decreasing the inflammation-related factors. Moreover, AOS 10 mg/kg could improve the blood metabolites related to immune and anti-tumor effects, and thus, ameliorated impaired liver function. The results indicate that AOS may be a potential therapy to deal with liver damage, especially in inflammatory conditions.