Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung

The intrinsic apoptosis pathway represents an important mechanism of stress-induced death of cancer cells. To gain insight into the functional status of the apoptosome apparatus in non-small cell lung carcinoma (NSCLC), we studied its sensitivity to activation, the assembly of apoptosome complexes a...

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Bibliographic Details
Published in:	International journal of oncology Vol. 44; no. 5; pp. 1443 - 1454
Main Authors:	MORAVCIKOVA, ERIKA, KREPELA, EVZEN, PROCHAZKA, JAN, BENKOVA, KAMILA, PAUK, NORBERT
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01-05-2014 Spandidos Publications Spandidos Publications UK Ltd
Subjects:	Aged Apaf-1 Apoptosis Apoptosis - drug effects apoptosome Apoptotic Protease-Activating Factor 1 - metabolism Brain cancer Cancer Cancer therapies Carcinoma Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology caspase Caspase 3 - metabolism Caspase 9 - metabolism Caspase Inhibitors - pharmacology Cell culture Cell Line, Tumor Cytochromes c - pharmacology Cytosol - metabolism Deoxyadenine Nucleotides - pharmacology Female Gene Expression Regulation, Neoplastic Humans Lung - cytology Lung - metabolism Lung cancer Lung cancer, Non-small cell Lung Neoplasms - metabolism Lung Neoplasms - pathology Lungs Male Middle Aged non-small cell lung carcinoma Oncology, Experimental Peptides Proteins Tumors X-linked inhibitor of apoptosis X-Linked Inhibitor of Apoptosis Protein - pharmacology United States > US
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