Stress-induced hyperthermia and infection-induced fever: Two of a kind?

• Published in: Physiology & behavior Vol. 98; no. 1; pp. 37 - 43
• Main Authors: Vinkers, Christiaan H, Groenink, Lucianne, van Bogaert, Meg J.V, Westphal, Koen G.C, Kalkman, Cor J, van Oorschot, Ruud, Oosting, Ronald S, Olivier, Berend, Korte, S. Mechiel
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 04-08-2009; Elsevier
• Subjects: Animals; Aspirin; Aspirin - pharmacology; Behavioral psychophysiology; Biological and medical sciences; Diazepam; Diazepam - pharmacology; Dose-Response Relationship, Drug; Electrodes, Implanted; Fever - chemically induced; Fever - etiology; Fever - physiopathology; Fundamental and applied biological sciences. Psychology; GABA Agonists - pharmacology; GABA-A Receptor Agonists; IL-1β; Infection - complications; Infection - physiopathology; Interleukin-1beta; Lipopolysaccharides - pharmacology; LPS; Male; Medical sciences; Mice; Mice, Inbred C57BL; Neuropharmacology; Pharmacology. Drug treatments; Prostaglandin Antagonists - pharmacology; Psychiatry; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychoneuroimmunology; Psychopharmacology; Rats; Rats, Wistar; Stress, Psychological - complications; Stress, Psychological - physiopathology; Telemetry; Aspirin; Psychoneuroimmunology; IL-1β; Diazepam; LPS; Prostaglandin-endoperoxide synthase; Psychotropic; Anticonvulsant; Acetylsalicylic acid; Lipopolysaccharide; Benzodiazepine derivatives; Salicylates; Enzyme; Cytokine; Enzyme inhibitor; Hypnotic; Interleukin 1β; Fever; Antiplatelet agent; Stress; Non steroidal antiinflammatory agent; Infection; Analgesic; Tranquillizer; Antipyretic; Oxidoreductases; Hyperthermia
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2009.04.004

Abstract Stress exposure activates the autonomic nervous system and leads to a body temperature increase (stress-induced hyperthermia, SIH). On the other hand, an activation of the immune system in response to an infection leads to fever. Both processes increase body temperature, and the relation between SIH and infection-induced fever has been subject to debate. It is not clear whether SIH is a form of fever, or whether both processes are more or less distinct. We therefore examined the relation between SIH and infection-induced fever by looking at the effects of a GABAA receptor agonist (diazepam) and a prostaglandin-synthesis blocking drug (acetylsalicylic acid, aspirin) on both the SIH response and fever in rats and mice. The present study shows that the benzodiazepine diazepam but not the prostaglandin-synthesis blocking drug aspirin dose-dependently attenuated the SIH response in both rats and mice. In contrast, aspirin reduced both LPS- and IL-1β induced fever, whereas diazepam had little effect on these fever states. Altogether, our findings support the hypothesis that stress-induced hyperthermia and infection-induced fever are two distinct processes mediated largely by different neurobiological mechanisms.