The ins and outs of microvesicles

Microvesicles are a heterogeneous group of membrane‐enclosed vesicles that are released from cells into the extracellular space by the outward budding and pinching of the plasma membrane. These vesicles are loaded with multiple selectively sorted proteins and nucleic acids. Although interest in the...

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Bibliographic Details
Published in:	FASEB bioAdvances Vol. 3; no. 6; pp. 399 - 406
Main Authors:	Clancy, James W., Schmidtmann, Madison, D’Souza‐Schorey, Crislyn
Format:	Journal Article
Language:	English
Published:	Bethesda John Wiley & Sons, Inc 01-06-2021 John Wiley and Sons Inc Wiley
Subjects:	Biosynthesis Breast cancer Hypoxia Kinases Membrane vesicles Plasma Regulation Review Reviews Roles
Online Access:	Get full text
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Summary:	Microvesicles are a heterogeneous group of membrane‐enclosed vesicles that are released from cells into the extracellular space by the outward budding and pinching of the plasma membrane. These vesicles are loaded with multiple selectively sorted proteins and nucleic acids. Although interest in the clinical potential of microvesicles is increasing, there is only limited understanding of different types of microvesicles and the mechanisms involved in their formation. Here, we describe what is presently known about this expanding and complex field of research focusing on the mechanism of biogenesis, cargo loading, and release of microvesicles.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 This article is part of the Extracellular Vesicles and Homeostasis Special Collection.
ISSN:	2573-9832 2573-9832
DOI:	10.1096/fba.2020-00127