The Impact of Mutant p53 in the Non-Coding RNA World

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 3; p. 472
• Main Author: Di Agostino, Silvia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19-03-2020; MDPI
• Subjects: cancer; circular rna (circrnas); Epigenesis, Genetic; extracellular rna (exrnas); gain-of-function; Gene Expression Regulation, Neoplastic; Humans; long non-coding rna (lncrnas); Methods; micro rna (mirnas); mutant p53; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Review; RNA sequencing; RNA, Neoplasm - genetics; RNA, Neoplasm - metabolism; RNA, Untranslated - genetics; RNA, Untranslated - metabolism; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Italy; mutant p53; long non-coding RNA (lncRNAs); extracellular RNA (exRNAs); gain-of-function; micro RNA (miRNAs); cancer; circular RNA (circRNAs)
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom10030472

Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), micro RNAs (miRNAs), and extracellular RNAs (exRNAs) are new groups of RNAs with regulation activities that have low or no protein-coding ability. Emerging evidence suggests that deregulated expression of these non-coding RNAs is associated with the induction and progression of diverse tumors throughout epigenetic, transcriptional, and post-transcriptional modifications. A consistent number of non-coding RNAs (ncRNAs) has been shown to be regulated by p53, the most important tumor suppressor of the cells frequently mutated in human cancer. It has been shown that some mutant p53 proteins are associated with the loss of tumor suppressor activity and the acquisition of new oncogenic functions named gain-of-function activities. In this review, we highlight recent lines of evidence suggesting that mutant p53 is involved in the expression of specific ncRNAs to gain oncogenic functions through the creation of a complex network of pathways that influence each other.