FOXO3 Depletion as a Marker of Compression-Induced Apoptosis in the Ligature Mark: An Immunohistochemical Study
One of the most challenging issues in forensic pathology is lesion vitality demonstration, particularly in cases of hanging. Over the past few years, immunohistochemistry has been applied to this field with promising results. In particular, protein and transcription factors involved in the apoptotic...
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| Published in: | International journal of molecular sciences Vol. 24; no. 2; p. 1396 |
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| Abstract | One of the most challenging issues in forensic pathology is lesion vitality demonstration, particularly in cases of hanging. Over the past few years, immunohistochemistry has been applied to this field with promising results. In particular, protein and transcription factors involved in the apoptotic process have been studied as vitality markers for the ligature mark. This study represents an implementation of our previous studies on ligature mark vitality demonstration. In this study, we evaluated the FOXO3 expression in post-mortem cervical skin samples through an immunohistochemical analysis. To evaluate FOXO3 expression, anti-FOXO3 antibodies (GTX100277) were used. The study group comprised 21 cases, 8 women and 13 men, whereas the control group consisted of 13 cases of subjects who died due to other causes. Decomposition and no clear circumstantial data were exclusion criteria. We found that FOXO3 is decreased in hanging cases compared with normal skin in other causes of death (p-value < 0.05). No differences were seen concerning the type of hanging material (hard or soft), type of hanging (complete or incomplete), and position of the knot. Our results suggest that FOXO3 depletion could be a valid immunohistochemical marker of ligature mark vitality. |
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| AbstractList | One of the most challenging issues in forensic pathology is lesion vitality demonstration, particularly in cases of hanging. Over the past few years, immunohistochemistry has been applied to this field with promising results. In particular, protein and transcription factors involved in the apoptotic process have been studied as vitality markers for the ligature mark. This study represents an implementation of our previous studies on ligature mark vitality demonstration. In this study, we evaluated the FOXO3 expression in post-mortem cervical skin samples through an immunohistochemical analysis. To evaluate FOXO3 expression, anti-FOXO3 antibodies (GTX100277) were used. The study group comprised 21 cases, 8 women and 13 men, whereas the control group consisted of 13 cases of subjects who died due to other causes. Decomposition and no clear circumstantial data were exclusion criteria. We found that FOXO3 is decreased in hanging cases compared with normal skin in other causes of death (p-value < 0.05). No differences were seen concerning the type of hanging material (hard or soft), type of hanging (complete or incomplete), and position of the knot. Our results suggest that FOXO3 depletion could be a valid immunohistochemical marker of ligature mark vitality. One of the most challenging issues in forensic pathology is lesion vitality demonstration, particularly in cases of hanging. Over the past few years, immunohistochemistry has been applied to this field with promising results. In particular, protein and transcription factors involved in the apoptotic process have been studied as vitality markers for the ligature mark. This study represents an implementation of our previous studies on ligature mark vitality demonstration. In this study, we evaluated the FOXO3 expression in post-mortem cervical skin samples through an immunohistochemical analysis. To evaluate FOXO3 expression, anti-FOXO3 antibodies (GTX100277) were used. The study group comprised 21 cases, 8 women and 13 men, whereas the control group consisted of 13 cases of subjects who died due to other causes. Decomposition and no clear circumstantial data were exclusion criteria. We found that FOXO3 is decreased in hanging cases compared with normal skin in other causes of death ( p -value < 0.05). No differences were seen concerning the type of hanging material (hard or soft), type of hanging (complete or incomplete), and position of the knot. Our results suggest that FOXO3 depletion could be a valid immunohistochemical marker of ligature mark vitality. |
| Author | Fineschi, Vittorio Del Duca, Fabio Turillazzi, Emanuela Frati, Paola Maiese, Aniello Santoro, Paola Manetti, Alice Chiara De Matteis, Alessandra |
| AuthorAffiliation | 2 Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, RM, Italy 1 Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, PI, Italy |
| AuthorAffiliation_xml | – name: 2 Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, RM, Italy – name: 1 Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, PI, Italy |
| Author_xml | – sequence: 1 givenname: Aniello surname: Maiese fullname: Maiese, Aniello organization: Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, PI, Italy – sequence: 2 givenname: Alice Chiara orcidid: 0000-0002-2664-028X surname: Manetti fullname: Manetti, Alice Chiara organization: Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, PI, Italy – sequence: 3 givenname: Paola surname: Santoro fullname: Santoro, Paola organization: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, RM, Italy – sequence: 4 givenname: Fabio orcidid: 0000-0002-6934-9791 surname: Del Duca fullname: Del Duca, Fabio organization: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, RM, Italy – sequence: 5 givenname: Alessandra surname: De Matteis fullname: De Matteis, Alessandra organization: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, RM, Italy – sequence: 6 givenname: Emanuela surname: Turillazzi fullname: Turillazzi, Emanuela organization: Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, PI, Italy – sequence: 7 givenname: Paola orcidid: 0000-0002-0358-7965 surname: Frati fullname: Frati, Paola organization: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, RM, Italy – sequence: 8 givenname: Vittorio orcidid: 0000-0002-1686-3236 surname: Fineschi fullname: Fineschi, Vittorio organization: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, RM, Italy |
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| Keywords | immunohistochemistry FOXO3 hanging vitality suicide |
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| Snippet | One of the most challenging issues in forensic pathology is lesion vitality demonstration, particularly in cases of hanging. Over the past few years,... |
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| SubjectTerms | Apoptosis Asphyxia - pathology Autopsies Autopsy Chemokines Compression Criminal investigations Cytoplasm Depletion Female Forensic Pathology Forensic science Forkhead Box Protein O3 FOXO3 FOXO3 protein hanging Humans Immunohistochemistry Ischemia Kinases Male MicroRNAs Protein expression Proteins Skin Suicide Transcription factors vitality |
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| Title | FOXO3 Depletion as a Marker of Compression-Induced Apoptosis in the Ligature Mark: An Immunohistochemical Study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36674912 https://www.proquest.com/docview/2767228176 https://search.proquest.com/docview/2768225995 https://pubmed.ncbi.nlm.nih.gov/PMC9866130 https://doaj.org/article/073dbdf1b71c4c2ba423b48341ffefa6 |
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