Spaceflight and development of immune responses
1 Department of General Surgery Research, Carolinas Medical Center, Charlotte, North Carolina 28232-2861; and 2 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106 The NIH.R1 Space Shuttle experiment was designed to study t...
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| Published in: | Journal of applied physiology (1985) Vol. 85; no. 4; pp. 1429 - 1433 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Bethesda, MD
Am Physiological Soc
01-10-1998
American Physiological Society |
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| Abstract | 1 Department of General Surgery
Research, Carolinas Medical Center, Charlotte, North Carolina
28232-2861; and 2 Department of
Pharmaceutical Sciences, School of Pharmacy, Texas Tech University
Health Sciences Center, Amarillo, Texas 79106
The NIH.R1 Space Shuttle experiment was
designed to study the effects of spaceflight on rodent development.
Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant
control rats were maintained in animal enclosure modules in a
ground-based chamber under conditions approximating those in flight.
Additional controls were in standard housing. The effects of the flight
on immunological parameters of dams, fetuses, and pups were determined. Blastogenesis of spleen cells in response to mitogen was inhibited in
flown dams but was not inhibited in cells from their pups. Interferon- production by spleen cells showed a trend toward inhibition in flown dams but not in their pups. The response of bone
marrow cells to colony-stimulating factor showed a trend toward
inhibition after spaceflight in dams, but the response of fetus and pup
liver cells was not inhibited. Total serum IgG was not affected by
spaceflight. None of the examined immune parameters that were altered
in rat dams after spaceflight was found to be altered in their
offspring.
antibody; development; cellular immunity |
|---|---|
| AbstractList | The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant control rats were maintained in animal enclosure modules in a ground-based chamber under conditions approximating those in flight. Additional controls were in standard housing. The effects of the flight on immunological parameters of dams, fetuses, and pups were determined. Blastogenesis of spleen cells in response to mitogen was inhibited in flown dams but was not inhibited in cells from their pups. Interferon-γ production by spleen cells showed a trend toward inhibition in flown dams but not in their pups. The response of bone marrow cells to colony-stimulating factor showed a trend toward inhibition after spaceflight in dams, but the response of fetus and pup liver cells was not inhibited. Total serum IgG was not affected by spaceflight. None of the examined immune parameters that were altered in rat dams after spaceflight was found to be altered in their offspring. The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant control rats were maintained in animal enclosure modules in a ground-based chamber under conditions approximating those in flight. Additional controls were in standard housing. The effects of the flight on immunological parameters of dams, fetuses, and pups were determined. Blastogenesis of spleen cells in response to mitogen was inhibited in flown dams but was not inhibited in cells from their pups. Interferon-gamma production by spleen cells showed a trend toward inhibition in flown dams but not in their pups. The response of bone marrow cells to colony-stimulating factor showed a trend toward inhibition after spaceflight in dams, but the response of fetus and pup liver cells was not inhibited. Total serum IgG was not affected by spaceflight. None of the examined immune parameters that were altered in rat dams after spaceflight was found to be altered in their offspring. The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant control rats were maintained in animal enclosure modules in a ground-based chamber under conditions approximating those in flight. Additional controls were in standard housing. The effects of the flight on immunological parameters of dams, fetuses, and pups were determined. Blastogenesis of spleen cells in response to mitogen was inhibited in flown dams but was not inhibited in cells from their pups. Interferon-gamma production by spleen cells showed a trend toward inhibition in flown dams but not in their pups. The response of bone marrow cells to colony-stimulating factor showed a trend toward inhibition after spaceflight in dams, but the response of fetus and pup liver cells was not inhibited. Total serum IgG was not affected by spaceflight. None of the examined immune parameters that were altered in rat dams after spaceflight was found to be altered in their offspring. (Author) The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant control rats were maintained in animal enclosure modules in a ground-based chamber under conditions approximating those in flight. 1 Department of General Surgery Research, Carolinas Medical Center, Charlotte, North Carolina 28232-2861; and 2 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106 The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant control rats were maintained in animal enclosure modules in a ground-based chamber under conditions approximating those in flight. Additional controls were in standard housing. The effects of the flight on immunological parameters of dams, fetuses, and pups were determined. Blastogenesis of spleen cells in response to mitogen was inhibited in flown dams but was not inhibited in cells from their pups. Interferon- production by spleen cells showed a trend toward inhibition in flown dams but not in their pups. The response of bone marrow cells to colony-stimulating factor showed a trend toward inhibition after spaceflight in dams, but the response of fetus and pup liver cells was not inhibited. Total serum IgG was not affected by spaceflight. None of the examined immune parameters that were altered in rat dams after spaceflight was found to be altered in their offspring. antibody; development; cellular immunity |
| Author | Sonnenfeld, Gerald Morton, Darla Fowler, Nina A Hakenewerth, Anne M Bates, Roge Miller, Edwin S., Jr Bailliard, Frederique Foster, Mareva |
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| Cites_doi | 10.1002/jlb.60.1.37 10.4049/jimmunol.113.4.1353 10.1002/jlb.54.3.253 10.1016/0094-5765(84)90078-X 10.1089/jir.1996.16.409 10.1002/jlb.52.1.104 10.1002/jlb.51.2.129 10.1126/science.6729476 10.1084/jem.142.3.802 10.1152/jappl.1995.78.3.810 10.1002/jlb.54.3.236 10.1002/jlb.54.3.202 10.1016/S0165-3806(97)00017-5 10.1152/jappl.1996.81.1.178 10.1530/jrf.0.1090193 10.1038/eye.1995.30 10.1002/jlb.54.3.189 10.1016/S1569-2574(08)60121-5 10.1006/brbi.1996.0035 10.1016/0014-4827(92)90411-Z 10.1016/S1569-2574(08)60076-3 10.1016/0024-3205(90)90509-P 10.1002/jlb.55.2.209 10.1006/brbi.1997.0483 |
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| Keywords | Vertebrata Mammalia Immune response Rat Rodentia Development Environmental factor Weightlessness Space flight Microgravity Immune system NASA Experiment Number 9303009 NASA Discipline Regulatory Physiology Non-NASA Center |
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| Snippet | 1 Department of General Surgery
Research, Carolinas Medical Center, Charlotte, North Carolina
28232-2861; and 2 Department of
Pharmaceutical Sciences, School... The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for... |
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| SubjectTerms | Anatomy & physiology Animals Antibody Formation Biological and medical sciences Child development Concanavalin A Effects Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immune system Immunity, Cellular Immunobiology Immunoglobulin G - blood Interferon-gamma - biosynthesis Lymphocyte Activation Lymphocytes - immunology Modulation of the immune response (stimulation, suppression) Pregnancy Pregnancy, Animal - immunology Prenatal Exposure Delayed Effects Rats Reference Values Space Space Flight Space life sciences |
| Title | Spaceflight and development of immune responses |
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