Bidirectional signals of PD-L1 in T cells that fraternize with cancer cells

Bidirectional signals of PD-L1 in T cells that fraternize with cancer cells

PD-L1 expressed by T cells provides backward and forward signals to restrain both innate and adaptive immune responses in tumor tissues.

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Bibliographic Details
Published in:Nature immunology Vol. 21; no. 4; pp. 365 - 366
Main Authors: Johnson, Rachel M. Gibbons, Wen, Ti, Dong, Haidong
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01-04-2020
Nature Publishing Group
Subjects:
631/250/1619/554/1834/1269
631/250/2152/569/2495
631/250/516
631/250/580/1884
631/67/580
Adaptive immunity
B7-H1 Antigen
Biomedical and Life Sciences
Biomedicine
Cancer cells
Growth
Health aspects
Immunological research
Immunology
Infectious Diseases
Lymphocytes T
Macrophages
News & Views
news-and-views
PD-L1 protein
Programmed Cell Death 1 Receptor
Self Tolerance
T cells
T-Lymphocytes
United States
Online Access:Get full text
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Description
Summary:PD-L1 expressed by T cells provides backward and forward signals to restrain both innate and adaptive immune responses in tumor tissues.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-020-0599-3