Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages

Electronegative low-density lipoprotein (LDL) (LDL(-)), a modified LDL that is present in blood and exerts atherogenic effects on endothelial cells and monocytes. This study aimed to determine the action of LDL(-) on monocytes differentiated into macrophages. LDL(-) and in vitro-modified LDLs (oxidi...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 9; no. 3; p. 583
Main Authors:	Puig, Núria, Montolio, Lara, Camps-Renom, Pol, Navarra, Laia, Jiménez-Altayó, Francesc, Jiménez-Xarrié, Elena, Sánchez-Quesada, Jose Luis, Benitez, Sonia
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-03-2020 MDPI
Subjects:	Apoptosis Atherosclerosis Cardiovascular disease CD14 antigen CD36 antigen Cell differentiation Cytokines electronegative ldl Endothelial cells Flow cytometry foam cells Gene expression Granulocytes hdl High density lipoprotein Humans Inflammation Inflammation - chemically induced lipid droplets Lipids Lipoproteins Lipoproteins, LDL - adverse effects Low density lipoprotein LOX-1 protein Macrophages Macrophages - immunology Monocytes Scavenger receptors Thin-layer chromatography tlr4 TLR4 protein Toll-like receptors triglycerides Triglycerides - adverse effects United States > US foam cells HDL macrophages inflammation electronegative LDL triglycerides lipid droplets TLR4 scavenger receptors
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