Histone H1 Depletion in Mammals Alters Global Chromatin Structure but Causes Specific Changes in Gene Regulation

Linker histone H1 plays an important role in chromatin folding in vitro. To study the role of H1 in vivo, mouse embryonic stem cells null for three H1 genes were derived and were found to have 50% of the normal level of H1. H1 depletion caused dramatic chromatin structure changes, including decrease...

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Bibliographic Details
Published in:	Cell Vol. 123; no. 7; pp. 1199 - 1212
Main Authors:	Fan, Yuhong, Nikitina, Tatiana, Zhao, Jie, Fleury, Tomara J., Bhattacharyya, Riddhi, Bouhassira, Eric E., Stein, Arnold, Woodcock, Christopher L., Skoultchi, Arthur I.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 29-12-2005
Subjects:	Animals Cell Line Chromatin - chemistry Chromatin - metabolism CpG Islands DNA Methylation Embryo Research Gene Expression Regulation Histones - genetics Histones - metabolism Histones - physiology Humans Mice Microarray Analysis Regulatory Sequences, Nucleic Acid Stem Cells - chemistry
Online Access:	Get full text
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