Defining the System: Contributors to Exercise Limitations in Heart Failure

One of the primary hallmarks of patients diagnosed with heart failure (HF) is a reduced tolerance to exercise and compromised functional capacity. This limitation stems from poor pumping capacity but also major changes in functioning of the vasculature, skeletal muscle, and respiratory systems. Adva...

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Bibliographic Details
Published in:	Heart failure clinics Vol. 11; no. 1; pp. 1 - 16
Main Authors:	Phillips, Shane A., PhD, PT, Vuckovic, Karen, RN, PhD, Cahalin, Lawrence P., PhD, PT, Baynard, Tracy, PhD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-01-2015
Subjects:	Cardiopulmonary Cardiovascular Exercise Exercise Therapy Exercise Tolerance - physiology Heart failure Heart Failure - physiopathology Heart Failure - rehabilitation Humans Intolerance Skeletal muscle Vascular Heart failure Intolerance Cardiopulmonary Exercise Vascular Skeletal muscle
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Summary:	One of the primary hallmarks of patients diagnosed with heart failure (HF) is a reduced tolerance to exercise and compromised functional capacity. This limitation stems from poor pumping capacity but also major changes in functioning of the vasculature, skeletal muscle, and respiratory systems. Advances in the understanding of the central and peripheral mechanisms of exercise intolerance during HF are critical for the future design of therapeutic modalities devised to improve outcomes. The interrelatedness between systems cannot be discounted. This review summarizes the current literature related to the pathophysiology of HF contributing to poor exercise tolerance, and potential mechanisms involved.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1551-7136 2374-9334
DOI:	10.1016/j.hfc.2014.08.009