The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells

• Published in: Cancer letters Vol. 360; no. 2; pp. 195 - 204
• Main Authors: Lee, Seung Woo, Kim, Hyun-Kyung, Lee, Na-Hyeon, Yi, Hee-Yeon, Kim, Hong-Sug, Hong, Sung Hee, Hong, Yong-Kil, Joe, Young Ae
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-05-2015; Elsevier Limited
• Subjects: Antineoplastic Combined Chemotherapy Protocols - pharmacology; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Autophagy - physiology; Cancer; Cancer therapies; Cell cycle; Cell growth; Cell Growth Processes - drug effects; Cell Line, Tumor; Chloroquine; Chloroquine - administration & dosage; Chloroquine - pharmacology; Cytotoxicity; Dacarbazine - administration & dosage; Dacarbazine - analogs & derivatives; Dacarbazine - pharmacology; Deoxyribonucleic acid; DNA; Drug dosages; Drug Synergism; Glioblastoma - drug therapy; Glioblastoma - metabolism; Glioblastoma - pathology; Glioma; Hematology, Oncology and Palliative Medicine; Humans; Kinases; p53; Signal transduction; Substance abuse treatment; Temozolomide; Tumor Suppressor Protein p53 - metabolism; Temozolomide; Glioma; Autophagy; Chloroquine; p53
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2015.02.012

Highlights • Combination of temozolomide and chloroquine creates a synergistic effect. • The synergistic effect from combination treatment of temozolomide and chloroquine is dependent on autophagy. • The pro-apopototic effect from combination treatment of temozolomide and chloroquine is dependent on p53.