Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration
The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL , and Transcutol HP were selected and confirmed t...
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| Published in: | Pharmaceutics Vol. 12; no. 4; p. 332 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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| Abstract | The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL
, and Transcutol
HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (w/w %) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (w/w %). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL
, and Transcutol
HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin. |
|---|---|
| AbstractList | The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL
®
, and Transcutol
®
HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (
w
/
w
%) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (
w
/
w
%). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL
®
, and Transcutol
®
HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin. The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL , and Transcutol HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (w/w %) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (w/w %). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL , and Transcutol HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin. The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL®, and Transcutol® HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (w/w %) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (w/w %). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL®, and Transcutol® HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin. |
| Author | Ryu, Kyeong-A Jang, Dong-Jin Park, Phil June Kim, Seong-Bo Bin, Bum-Ho Kim, Sung Tae |
| AuthorAffiliation | 5 Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Korea 2 Department of Genetic Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do 16499, Korea; philjunep@gmail.com 1 Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Korea; rkakk95050@oasis.inje.ac.kr 4 Department of Biological Sciences, Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea; bhb@ajou.ac.kr 3 Bio-Living Engineering Major, Global Leaders College, Yonsei University, 50 yonsei-ro, Shinchon-dong, Seodaemun-gu, Seoul 03722, Korea; seongbo.kim@yonsei.ac.kr |
| AuthorAffiliation_xml | – name: 3 Bio-Living Engineering Major, Global Leaders College, Yonsei University, 50 yonsei-ro, Shinchon-dong, Seodaemun-gu, Seoul 03722, Korea; seongbo.kim@yonsei.ac.kr – name: 4 Department of Biological Sciences, Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea; bhb@ajou.ac.kr – name: 1 Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Korea; rkakk95050@oasis.inje.ac.kr – name: 5 Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Korea – name: 2 Department of Genetic Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do 16499, Korea; philjunep@gmail.com |
| Author_xml | – sequence: 1 givenname: Kyeong-A surname: Ryu fullname: Ryu, Kyeong-A organization: Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Korea – sequence: 2 givenname: Phil June surname: Park fullname: Park, Phil June organization: Department of Genetic Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do 16499, Korea – sequence: 3 givenname: Seong-Bo surname: Kim fullname: Kim, Seong-Bo organization: Bio-Living Engineering Major, Global Leaders College, Yonsei University, 50 yonsei-ro, Shinchon-dong, Seodaemun-gu, Seoul 03722, Korea – sequence: 4 givenname: Bum-Ho surname: Bin fullname: Bin, Bum-Ho organization: Department of Biological Sciences, Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea – sequence: 5 givenname: Dong-Jin surname: Jang fullname: Jang, Dong-Jin organization: Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Korea – sequence: 6 givenname: Sung Tae surname: Kim fullname: Kim, Sung Tae organization: Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32272811$$D View this record in MEDLINE/PubMed |
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| Keywords | coenzyme Q10 microemulsion topical administration skin regeneration |
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| Title | Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration |
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