Herpes Simplex Virus-Specific Memory CD8 + T Cells Are Selectively Activated and Retained in Latently Infected Sensory Ganglia

This study challenges the concept that herpes simplex virus type 1 (HSV-1) latency represents a silent infection that is ignored by the host immune system, and suggests antigen-directed retention of memory CD8 + T cells. CD8 + T cells specific for the immunodominant gB 498-505 HSV-1 epitope are sele...

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Bibliographic Details

Published in:	Immunity (Cambridge, Mass.) Vol. 18; no. 5; pp. 593 - 603
Main Authors:	Khanna, Kamal M., Bonneau, Robert H., Kinchington, Paul R., Hendricks, Robert L.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-05-2003 Elsevier Limited
Subjects:	Animals CD8-Positive T-Lymphocytes - immunology Epitopes - immunology Gene expression Herpes Simplex - immunology Immunologic Memory - immunology Infections Lymphocytes Mice Mice, Inbred C57BL Peptides Simplexvirus - immunology Trigeminal Ganglion - immunology Trigeminal Ganglion - virology Virus Latency - immunology
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