Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight management

• Published in: PloS one Vol. 18; no. 7; p. e0282401
• Main Authors: Jebeile, Hiba, Lister, Natalie B, Libesman, Sol, Hunter, Kylie E, McMaster, Caitlin M, Johnson, Brittany J, Baur, Louise A, Paxton, Susan J, Garnett, Sarah P, Ahern, Amy L, Wilfley, Denise E, Maguire, Sarah, Sainsbury, Amanda, Steinbeck, Katharine, Askie, Lisa, Braet, Caroline, Hill, Andrew J, Nicholls, Dasha, Jones, Rebecca A, Dammery, Genevieve, Grunseit, Alicia M, Cooper, Kelly, Kyle, Theodore K, Heeren, Faith A, Quigley, Fiona, Barnes, Rachel D, Bean, Melanie K, Beaulieu, Kristine, Bonham, Maxine, Boutelle, Kerri N, Branco, Braulio Henrique Magnani, Calugi, Simona, Cardel, Michelle I, Carpenter, Kelly, Cheng, Hoi Lun, Dalle Grave, Riccardo, Danielsen, Yngvild S, Demarzo, Marcelo, Dordevic, Aimee, Eichen, Dawn M, Goldschmidt, Andrea B, Hilbert, Anja, Houben, Katrijn, Lofrano do Prado, Mara, Martin, Corby K, McTiernan, Anne, Mensinger, Janell L, Pacanowski, Carly, do Prado, Wagner Luiz, Ramalho, Sofia M, Raynor, Hollie A, Rieger, Elizabeth, Robinson, Eric, Salvo, Vera, Sherwood, Nancy E, Simpson, Sharon A, Skjakodegard, Hanna F, Smith, Evelyn, Partridge, Stephanie, Tanofsky-Kraff, Marian, Taylor, Rachael W, Van Eyck, Annelies, Varady, Krista A, Vidmar, Alaina P, Whitelock, Victoria, Yanovski, Jack, Seidler, Anna L
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10-07-2023; Public Library of Science (PLoS)
• Subjects: Adolescent; Adolescents; Adult; Adults; Behavior; Behavior Therapy; Binge eating; Biology and Life Sciences; Body mass index; Body weight; Care and treatment; Clinical trials; Collaboration; Complications and side effects; Computer and Information Sciences; Data analysis; Diabetes; Eating disorders; Feeding and Eating Disorders - therapy; Gastrointestinal surgery; Health aspects; Health risks; Humans; Intervention; Medicine and Health Sciences; Meta-analysis; Meta-Analysis as Topic; Obesity; Obesity in adolescence; Overweight; Overweight - complications; Overweight - therapy; Physical Sciences; Prevention; Questionnaires; Research and Analysis Methods; Risk factors; Risk taking; Signs and symptoms; Sleep; Study Protocol; Systematic review; Systematic Reviews as Topic; Teenagers; Weight control; Weight loss; United States
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0282401

The Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that contribute to eating disorder risk. We present a protocol for a systematic review and individual participant data (IPD) meta-analysis which aims to identify participants at risk of developing eating disorders, or related symptoms, during or after weight management interventions conducted in adolescents or adults with overweight or obesity. We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of weight management interventions conducted in adolescents or adults with overweight or obesity that measured eating disorder risk at pre- and post-intervention or follow-up. Authors from eligible trials have been invited to share their deidentified IPD. Two IPD meta-analyses will be conducted. The first IPD meta-analysis aims to examine participant level factors associated with a change in eating disorder scores during and following a weight management intervention. To do this we will examine baseline variables that predict change in eating disorder risk within intervention arms. The second IPD meta-analysis aims to assess whether there are participant level factors that predict whether participation in an intervention is more or less likely than no intervention to lead to a change in eating disorder risk. To do this, we will examine if there are differences in predictors of eating disorder risk between intervention and no-treatment control arms. The primary outcome will be a standardised mean difference in global eating disorder score from baseline to immediately post-intervention and at 6- and 12- months follow-up. Identifying participant level risk factors predicting eating disorder risk will inform screening and monitoring protocols to allow early identification and intervention for those at risk.