Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model

• Published in: The Annals of thoracic surgery Vol. 71; no. 5; pp. 1603 - 1608
• Main Authors: Suhara, Hitoshi, Sawa, Yoshiki, Nishimura, Motonobu, Oshiyama, Hiroaki, Yokoyama, Kenji, Saito, Noboru, Matsuda, Hikaru
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-05-2001; Elsevier Science
• Subjects: Acrylates; Anesthesia; Anesthesia depending on type of surgery; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Antithrombin III; Biological and medical sciences; Bradykinin - blood; Cardiopulmonary Bypass - instrumentation; Coated Materials, Biocompatible; Female; Fibrinogen - metabolism; Heparin; Materials Testing; Medical sciences; Peptide Hydrolases - blood; Polymers; Swine; Thoracic and cardiovascular surgery. Cardiopulmonary bypass; Coating material; Exploration; Pig; Cardiopulmonary bypass; Vertebrata; Mammalia; Acrylate polymer; Hemostasis; Animal; Artiodactyla; Heparin; Technique; Ungulata; Comparative study
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/S0003-4975(01)02466-3

Background. A new coating material, poly-2-methoxyethyl acrylate (PMEA), was developed to improve the biocompatibility of cardiopulmonary bypass (CPB) circuits.
Methods. To investigate the efficacy of the PMEA coating for CPB circuits, we compared PMEA-coated circuits (group P, n = 6) with uncoated circuits (group C, n = 6) and heparin (covalent-bonded heparin, Hepaface)-coated circuits (group H, n = 6) in a porcine CPB model.
Results. Platelet counts were significantly preserved in groups P and H compared with those in group C (P versus C, p < 0.05). The plasma levels of thrombin-antithrombin complex and bradykinin were significantly lower at 120 minutes in groups P and H than in group C (thrombin-antithrombin: P versus C, p < 0.05; bradykinin: P versus C, p < 0.05). The amount of fibrinogen adsorbed onto the hollow fibers was markedly less in group P than in groups C and H.
Conclusions. The PMEA coating was equal to heparin coating in preventing reactions induced by CPB circuits, and might be superior to heparin coating in suppressing the adsorption of plasma proteins such as fibrinogen. Thus, PMEA coating may be a suitable means for improving the biocompatibility of CPB circuits.