Why Boys Will Be Boys: Two Pathways of Fetal Testicular Androgen Biosynthesis Are Needed for Male Sexual Differentiation

Human sexual determination is initiated by a cascade of genes that lead to the development of the fetal gonad. Whereas development of the female external genitalia does not require fetal ovarian hormones, male genital development requires the action of testicular testosterone and its more potent der...

Full description

Saved in:

Bibliographic Details
Published in:	American journal of human genetics Vol. 89; no. 2; pp. 201 - 218
Main Authors:	Flück, Christa E., Meyer-Böni, Monika, Pandey, Amit V., Kempná, Petra, Miller, Walter L., Schoenle, Eugen J., Biason-Lauber, Anna
Format:	Journal Article
Language:	English
Published:	Cambridge, MA Elsevier Inc 12-08-2011 Cell Press Elsevier
Subjects:	Alternative Splicing - genetics Amino Acid Sequence Androgens Androgens - biosynthesis Base Sequence Biological and medical sciences Biosynthesis Biosynthetic Pathways Cholesterol Dihydrotestosterone - metabolism Family Female Fetus - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation General aspects. Genetic counseling Genes Genetics of eukaryotes. Biological and molecular evolution Humans Hydroxysteroid Dehydrogenases - chemistry Hydroxysteroid Dehydrogenases - genetics Hydroxysteroid Dehydrogenases - metabolism Male Medical genetics Medical sciences Men Models, Molecular Molecular and cellular biology Molecular Sequence Data Mutant Proteins - metabolism Mutation Mutation - genetics Oxidoreductases - chemistry Oxidoreductases - genetics Oxidoreductases - metabolism Pedigree Sex Differentiation Testis - embryology Testis - metabolism Human Need Androgen Fetus Genetics Male Biosynthesis Testicle Sexual differentiation Child
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!