Transmission Cluster of Multiclass Highly Drug-Resistant HIV-1 Among 9 Men Who Have Sex With Men in Seattle/King County, WA, 2005-2007

BACKGROUND:From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Was...

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Published in:Journal of acquired immune deficiency syndromes (1999) Vol. 49; no. 2; pp. 205 - 211
Main Authors: Buskin, Susan E, Ellis, Giovanina M, Pepper, Gregory G, Frenkel, Lisa M, Pergam, Steven A, Gottlieb, Geoffrey S, Horwitch, Carrie, Olliffe, Jeffrey F, Johnson, Karen, Shalit, Peter, Heinen, Corinne, Schwartz, Margot, Wood, Robert W
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Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01-10-2008
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Abstract BACKGROUND:From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals. METHODS:HIV-1 pol nucleotide consensus sequences submitted to the University of Washington Clinical Virology Laboratory were assessed for phylogenetically related MDR HIV. Demographic and clinical data collected included HIV diagnosis date, ARV history, and laboratory results. RESULTS:Seven ARV-naive men had phylogenetically linked MDR strains with resistance to most ARVs; these were linked to 2 ARV-experienced men. All 9 men reported methamphetamine use and multiple anonymous male partners. Primary transmissions were diagnosed for more than a 2-year period, 2005-2007. Three, including the 2 ARV-experienced men, were prescribed ARVs. CONCLUSIONS:This cluster of 9 men with phylogenetically related highly drug-resistant MDR HIV strains and common risk factors but without reported direct epidemiologic links may have important implications to public health. This cluster demonstrates the importance of primary resistance testing and of collaboration between the public and private medical community in identifying MDR outbreaks. Public health interventions and surveillance are needed to reduce transmission of MDR HIV-1.
AbstractList From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals. HIV-1 pol nucleotide consensus sequences submitted to the University of Washington Clinical Virology Laboratory were assessed for phylogenetically related MDR HIV. Demographic and clinical data collected included HIV diagnosis date, ARV history, and laboratory results. Seven ARV-naive men had phylogenetically linked MDR strains with resistance to most ARVs; these were linked to 2 ARV-experienced men. All 9 men reported methamphetamine use and multiple anonymous male partners. Primary transmissions were diagnosed for more than a 2-year period, 2005-2007. Three, including the 2 ARV-experienced men, were prescribed ARVs. This cluster of 9 men with phylogenetically related highly drug-resistant MDR HIV strains and common risk factors but without reported direct epidemiologic links may have important implications to public health. This cluster demonstrates the importance of primary resistance testing and of collaboration between the public and private medical community in identifying MDR outbreaks. Public health interventions and surveillance are needed to reduce transmission of MDR HIV-1.
From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals. HIV-1 pol nucleotide consensus sequences submitted to the University of Washington Clinical Virology Laboratory were assessed for phylogenetically related MDR HIV. Demographic and clinical data collected included HIV diagnosis date, ARV history, and laboratory results. Seven ARV-naive men had phylogenetically linked MDR strains with resistance to most ARVs; these were linked to 2 ARV-experienced men. All 9 men reported methamphetamine use and multiple anonymous male partners. Primary transmissions were diagnosed for more than a 2-year period, 2005- 2007. Three, including the 2 ARV-experienced men, were prescribed ARVs. This cluster of 9 men with phylogenetically related highly drug-resistant MDR HIV strains and common risk factors but without reported direct epidemiologic links may have important implications to public health. This cluster demonstrates the importance of primary resistance testing and of collaboration between the public and private medical community in identifying MDR outbreaks. Public health interventions and surveillance are needed to reduce transmission of MDR HIV-1.
BACKGROUND:From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals. METHODS:HIV-1 pol nucleotide consensus sequences submitted to the University of Washington Clinical Virology Laboratory were assessed for phylogenetically related MDR HIV. Demographic and clinical data collected included HIV diagnosis date, ARV history, and laboratory results. RESULTS:Seven ARV-naive men had phylogenetically linked MDR strains with resistance to most ARVs; these were linked to 2 ARV-experienced men. All 9 men reported methamphetamine use and multiple anonymous male partners. Primary transmissions were diagnosed for more than a 2-year period, 2005-2007. Three, including the 2 ARV-experienced men, were prescribed ARVs. CONCLUSIONS:This cluster of 9 men with phylogenetically related highly drug-resistant MDR HIV strains and common risk factors but without reported direct epidemiologic links may have important implications to public health. This cluster demonstrates the importance of primary resistance testing and of collaboration between the public and private medical community in identifying MDR outbreaks. Public health interventions and surveillance are needed to reduce transmission of MDR HIV-1.
Background: From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals. Methods: HIV-1 pol nucleotide consensus sequences submitted to the University of Washington Clinical Virology Laboratory were assessed for phylogenetically related MDR HIV. Demographic and clinical data collected included HIV diagnosis date, ARV history, and laboratory results. Results: Seven ARV-naive men had phylogenetically linked MDR strains with resistance to most ARVs; these were linked to 2 ARV-experienced men. All 9 men reported methamphetamine use and multiple anonymous male partners. Primary transmissions were diagnosed for more than a 2-year period, 2005-2007. Three, including the 2 ARV-experienced men, were prescribed ARVs. Conclusions: This cluster of 9 men with phylogenetically related highly drug-resistant MDR HIV strains and common risk factors but without reported direct epidemiologic links may have important implications to public health. This cluster demonstrates the importance of primary resistance testing and of collaboration between the public and private medical community in identifying MDR outbreaks. Public health interventions and surveillance are needed to reduce transmission of MDR HIV-1.
BACKGROUNDFrom 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals. METHODSHIV-1 pol nucleotide consensus sequences submitted to the University of Washington Clinical Virology Laboratory were assessed for phylogenetically related MDR HIV. Demographic and clinical data collected included HIV diagnosis date, ARV history, and laboratory results. RESULTSSeven ARV-naive men had phylogenetically linked MDR strains with resistance to most ARVs; these were linked to 2 ARV-experienced men. All 9 men reported methamphetamine use and multiple anonymous male partners. Primary transmissions were diagnosed for more than a 2-year period, 2005-2007. Three, including the 2 ARV-experienced men, were prescribed ARVs. CONCLUSIONSThis cluster of 9 men with phylogenetically related highly drug-resistant MDR HIV strains and common risk factors but without reported direct epidemiologic links may have important implications to public health. This cluster demonstrates the importance of primary resistance testing and of collaboration between the public and private medical community in identifying MDR outbreaks. Public health interventions and surveillance are needed to reduce transmission of MDR HIV-1.
Author Buskin, Susan E
Schwartz, Margot
Pepper, Gregory G
Frenkel, Lisa M
Horwitch, Carrie
Olliffe, Jeffrey F
Johnson, Karen
Shalit, Peter
Wood, Robert W
Gottlieb, Geoffrey S
Pergam, Steven A
Heinen, Corinne
Ellis, Giovanina M
AuthorAffiliation From the HIV/AIDS Epidemiology Unit, HIV/AIDS Program, Public Health-Seattle & King County, Seattle, WA; †Departments of Epidemiology, Laboratory Medicine, Pediatrics, Allergy and Infectious Diseases, Family Medicine, Medicine, and Health Services, University of Washington, Seattle, WA; ‡Department of Childhood Infection, Seattle Childrenʼs Hospital Research Institute, Seattle, WA; §Virginia Mason Medical Center, Seattle, WA; ‖Country Doctor Community Clinic, Seattle, WA; and ¶Department of HIV Research, Swedish Medical Center, Seattle, WA
AuthorAffiliation_xml – name: From the HIV/AIDS Epidemiology Unit, HIV/AIDS Program, Public Health-Seattle & King County, Seattle, WA; †Departments of Epidemiology, Laboratory Medicine, Pediatrics, Allergy and Infectious Diseases, Family Medicine, Medicine, and Health Services, University of Washington, Seattle, WA; ‡Department of Childhood Infection, Seattle Childrenʼs Hospital Research Institute, Seattle, WA; §Virginia Mason Medical Center, Seattle, WA; ‖Country Doctor Community Clinic, Seattle, WA; and ¶Department of HIV Research, Swedish Medical Center, Seattle, WA
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  organization: From the HIV/AIDS Epidemiology Unit, HIV/AIDS Program, Public Health-Seattle & King County, Seattle, WA; †Departments of Epidemiology, Laboratory Medicine, Pediatrics, Allergy and Infectious Diseases, Family Medicine, Medicine, and Health Services, University of Washington, Seattle, WA; ‡Department of Childhood Infection, Seattle Childrenʼs Hospital Research Institute, Seattle, WA; §Virginia Mason Medical Center, Seattle, WA; ‖Country Doctor Community Clinic, Seattle, WA; and ¶Department of HIV Research, Swedish Medical Center, Seattle, WA
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Keywords multiple drug resistance
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Microbiology
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Snippet BACKGROUND:From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of...
From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to...
Background: From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of...
BACKGROUNDFrom 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of...
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SubjectTerms AIDS/HIV
Anti-HIV Agents - therapeutic use
Biological and medical sciences
Contact Tracing
Disease Outbreaks
Disease transmission
Drug resistance
Drug Resistance, Multiple, Viral
Drug therapy
Epidemiology
Fundamental and applied biological sciences. Psychology
Gays & lesbians
Genetics
HIV
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - classification
HIV-1 - drug effects
HIV-1 - isolation & purification
Homosexuality, Male
Human immunodeficiency virus
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Miscellaneous
Phylogeny
pol Gene Products, Human Immunodeficiency Virus - genetics
Risk factors
RNA, Viral - genetics
Sequence Analysis, DNA
Sexual Partners
Viral diseases
Virology
Washington - epidemiology
Title Transmission Cluster of Multiclass Highly Drug-Resistant HIV-1 Among 9 Men Who Have Sex With Men in Seattle/King County, WA, 2005-2007
URI https://www.ncbi.nlm.nih.gov/pubmed/18769347
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https://search.proquest.com/docview/20966700
https://search.proquest.com/docview/69612698
https://pubmed.ncbi.nlm.nih.gov/PMC2586929
Volume 49
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