The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking

ABSTRACT A major problem in treating alcohol use disorders (AUDs) is the high rate of relapse due to stress and re‐exposure to cues or an environment previously associated with alcohol use. Stressors can induce relapse to alcohol‐seeking in humans or reinstatement in rodents. Delta opioid peptide re...

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Bibliographic Details
Published in:	Addiction biology Vol. 17; no. 2; pp. 224 - 234
Main Authors:	Nielsen, Carsten K., Simms, Jeffrey A., Bito-Onon, Jade J., Li, Rui, Ananthan, Subramaniam, Bartlett, Selena E.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-03-2012
Subjects:	Addiction Adrenergic alpha-2 Receptor Antagonists - pharmacology Alcohol Drinking - prevention & control Alcoholic beverages Animals Brain Conditioning, Operant - drug effects Corticosterone Corticosterone - physiology Cues delta opioid receptor antagonist Drug self-administration Drug-Seeking Behavior - drug effects Ethanol ethanol-seeking Extinction Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Male Mesencephalon - metabolism Morphine Derivatives - pharmacology Operant conditioning Opioid receptors (type delta) Plasma levels Quinolines - pharmacology Rats Rats, Long-Evans Receptors, Opioid, delta - antagonists & inhibitors Reinforcement Reinforcement Schedule Reinstatement Self Administration SoRI-9409 Stress Stress, Psychological - psychology stress-induced reinstatement yohimbine Yohimbine - pharmacology
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