High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function

Summary Decorin (DCN), a component of the extracellular matrix of the peritubular wall and the interstitial areas of the human testis, can interact with growth factor (GF) signalling, thereby blocking downstream actions of GFs. In the present study the expression and regulation of DCN using both hum...

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Bibliographic Details
Published in:	International journal of andrology Vol. 35; no. 4; pp. 550 - 561
Main Authors:	Adam, M., Urbanski, H. F., Garyfallou, V. T., Welsch, U., Köhn, F. M., Ullrich Schwarzer, J., Strauss, L., Poutanen, M., Mayerhofer, A.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-08-2012 Blackwell
Subjects:	Animals Biological and medical sciences Birth control Cells, Cultured Decorin - metabolism development Disease Models, Animal Extracellular Matrix Proteins - metabolism Fibrosis Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans infertility Infertility, Male - pathology Inflammation Macaca mulatta Male Male genital diseases Mammalian male genital system Medical sciences Mice Mice, Transgenic mouse < animal models primates < animal models proteoglycan Signal Transduction Sterility. Assisted procreation testis Testis - cytology Testis - metabolism Testis - pathology Tumor Necrosis Factor-alpha - biosynthesis Vertebrates: reproduction Proteoglycan Animal model primates < animal models Rodentia mouse < animal models Inflammation testis Testicle infertility Male genital system Sterility Vertebrata Reproduction Mammalia Mouse Animal Fibrosis Development Extracellular matrix
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