FAK alternative splice mRNA variants expression pattern in colorectal cancer

The Focal adhesion kinase (FAK) is a ubiquitous cytoplasmic tyrosine‐kinase promoting tumor progression and metastasis processes by acting in cancer cells and their tumor microenvironment partners. FAK overexpression in primary colon tumors and their metastasis is associated to poor colorectal cance...

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Bibliographic Details
Published in:	International journal of cancer Vol. 145; no. 2; pp. 494 - 502
Main Authors:	Devaud, Christel, Tilkin‐Mariamé, Anne‐Françoise, Vignolle‐Vidoni, Alix, Souleres, Philippine, Denadai‐Souza, Alexandre, Rolland, Corinne, Duthoit, Christine, Blanpied, Catherine, Chabot, Sophie, Bouillé, Pascale, Lluel, Philippe, Vergnolle, Nathalie, Racaud‐Sultan, Claire, Ferrand, Audrey
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 15-07-2019 Wiley Subscription Services, Inc Wiley
Subjects:	Alternative Splicing Animal models Animals Biochemistry, Molecular Biology Biomarkers, Tumor - genetics Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology FAK Female Focal adhesion kinase Focal Adhesion Kinase 1 - genetics Gene expression Gene Expression Regulation, Neoplastic Genomics HCT116 Cells HT29 Cells Humans Invasiveness Isoforms Kinases Life Sciences Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - secondary Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - secondary Lungs Medical research Metastases Metastasis Mice Molecular Cancer Biology mRNA Neoplasm Invasiveness Neoplasm Transplantation RNA Isoforms - genetics Therapeutic applications Tumors Up-Regulation FAK metastases colorectal cancer alternative splicing
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