Subclinical Myocardial Impairment Occurred in Septal and Anterior LV Wall Segments After Anthracycline-Embedded Chemotherapy and did not Worsen During Adjuvant Trastuzumab Treatment in Breast Cancer Patients

In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin ® ) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at...

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Bibliographic Details
Published in:	Cardiovascular toxicology Vol. 16; no. 2; pp. 193 - 206
Main Authors:	Lange, Stefan Andreas, Jung, Jens, Jaeck, Almut, Hitschold, Thomas, Ebner, Bernd
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-04-2016 Springer Springer Nature B.V
Subjects:	Adjuvant treatment Adult Aged Anthracyclines Anthracyclines - administration & dosage Antineoplastic Agents - administration & dosage Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Cancer Cancer patients Cancer therapies Cardiology Chemotherapy Chemotherapy, Adjuvant - methods Cohort Studies Drug therapy Female Follow-Up Studies Health aspects Heart Heart Septum - drug effects Heart Septum - physiology Heart Ventricles - drug effects Humans Medical research Medicine, Experimental Middle Aged Patients Pharmacology/Toxicology Prospective Studies Trastuzumab - administration & dosage Treatment Outcome Ventricular Function, Left - drug effects Ventricular Function, Left - physiology Women Worms Germany 2D echocardiography Anthracyclines Breast cancer Cardiomyopathy
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