Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales

Rationale and Objectives The prefrontal cortex is critical for execution and inhibition of reward seeking. Neural manipulation of rodent medial prefrontal cortex (mPFC) subregions differentially impacts execution and inhibition of cocaine seeking. Dorsal, or prelimbic (PL), and ventral, or infralimb...

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Bibliographic Details
Published in:	Psychopharmacology Vol. 240; no. 3; pp. 575 - 594
Main Authors:	Moorman, David E., Aston-Jones, Gary
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2023 Springer Springer Nature B.V
Subjects:	Addictions Analysis Biomedical and Life Sciences Biomedicine Cocaine Cocaine - pharmacology Cues Drug addiction Drug self-administration Drug-Seeking Behavior - physiology Extinction behavior Extinction, Psychological - physiology Health aspects Neurons Neurosciences Original Investigation Pharmacology/Toxicology Prefrontal cortex Prefrontal Cortex - physiology Psychiatry Psychological aspects Reinstatement Reward Self Administration United States Learning Drug abuse Relapse Extinction Reinstatement Dependence Ensemble Psychostimulant
Online Access:	Get full text
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