Bipolar disorder: recent advances and future trends in bioanalytical developments for biomarker discovery

• Published in: Analytical and bioanalytical chemistry Vol. 407; no. 3; pp. 661 - 667
• Main Authors: de Jesus, Jemmyson Romário, de Campos, Bruna Kauely, Galazzi, Rodrigo Moretto, Martinez, José Luis Capelo, Arruda, Marco Aurélio Zezzi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-01-2015; Springer; Springer Nature B.V
• Subjects: ABCs 13th Anniversary; Analytical Chemistry; Analyzers; Biochemistry; Biological markers; Biomarkers; Biomarkers - analysis; Bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - etiology; Bipolar Disorder - metabolism; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Diagnosis; Disease; Disorders; Drugs; Emotional disorders; Emotions; Food Science; Genetic aspects; Humans; Illnesses; Laboratory Medicine; Mass spectrometry; Medical services; Mental depression; Mental disorders; Methods; Molecular diagnostic techniques; Monitoring/Environmental Analysis; Mood disorders; Patients; Physiological aspects; Proteins; Proteomics; Proteomics - methods; Schizophrenia; Scientific imaging; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Strategy; Trends; Portugal; Brazil; Mood disorders; Bipolar disorder; Experimental approaches; Blood biomarkers
• ISSN: 1618-2642; 1618-2650
• DOI: 10.1007/s00216-014-8341-3

In this manuscript we briefly describe bipolar disorder (a depressive and manic mental disease), its classification, its effects on the patient, which sometimes include suicidal tendencies, and the drugs used for treatment. We also address the status quo with regard to diagnosis of bipolar disorder and recent advances in bioanalytical approaches for biomarker discovery. These approaches focus on blood samples (serum and plasma) and proteins as the main biomarker targets, and use various strategies for protein depletion. Strategies include use of commercially available kits or other homemade strategies and use of classical proteomics methods for protein identification based on “bottom-up” or “top-down” approaches, which used SELDI, ESI, or MALDI as sources for mass spectrometry, and up-to-date mass analyzers, for example Orbitrap. We also discuss some future objectives for treatment of this disorder and possible directions for the correct diagnosis of this still-unclear mental illness.